131609-34-2Relevant articles and documents
Phosphodiesterase inhibitors.
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, (2008/06/13)
A compound of formula (I), or a pharmaceutically acceptable salt thereof: in which, R1 is hydrogen, C1-6 alkyl or CH2OR6; R2 is hydrogen or C1-6 alkyl; R3 is hydrogen or C1-6 alkyl; each of W and Z, which are different, represents -CR4R5- or -(CRxRy)n-, in which, R4 is hydrogen, C1-3 alkyl, C1-3 alkylthio, C1-3 alkoxy or C1-6 alkyl phenyl; R5 is C1-3 alkyl, C1-3 alkylthio, C1-3 alkoxy, phenyl, substituted phenyl, C3-6 cycloalkyl, phenylthio, C1-6 alkyl phenyl, halo-substituted benzyl, or heteroaryl; or together R4 and R5 form a 3 to 6 membered carbocyclic ring, or a heterocyclic ring containing one or two ring oxygen, nitrogen or sulphur atoms, or R4 and R5 together form an oxo or methylene group; each of Rx and Ry is hydrogen or C1-3 alkyl; n is zero or 1; R6 is phenyl substituted aminocarbonyl, C1-6 alkoxy carbonyl-C1-6 alkyl, phenyl-C1-6 alkyl, phenyl, C3-6 cycloalkylcarbonyl, C3-6 cycloalkylcarbonyl-C1-6 alkyl, C3-6 cycloalkyl C1-6 alkyl; C1-6 alkylthiocarbonyl; halo-substituted C1-6 alkoxycarbonyl; C1-6 alkoxy C1-6 alkyleneoxycarbonyl; C1-6 alkylthio C1-6 alkyleneoxycarbonyl; C1-6 alkoxythiocarbonyl; C3-6 cycloalkyloxycarbonyl; cyano substituted C1-6 alkoxycarbonyl; di-C1-6 alkylphosphonate; C1-6 alkenyloxycarbonyl; or R6 is hydrogen when R5 is phenyl, C3-6 cycloalkyl, phenylthio, C1-6 alkylphenyl or halo-substituted benzyl; R6 is benzoyl or aminobenzoyl when R4 and R5 form a C3-6 cycloalkyl ring; R7 is hydrogen, C1-6 alkyl or halogen; X is oxygen or sulphur; and A is sulphur, oxygen or -NH-, is useful for the treatment of heart disease
