1316097-98-9Relevant academic research and scientific papers
Highly Efficient Asymmetric Aziridination of Unsaturated Aldehydes Promoted by Chiral Hetero-organic Catalysts
Rachwalski, Micha?,Wujkowska, Zuzanna,Les?niak, Stanis?aw,Kie?basiński, Piotr
, p. 3589 - 3592 (2015)
Optically pure hetero-organic catalysts that bear a hydroxyl moiety, a stereogenic sulfinyl group, and a chiral amine moiety, are highly efficient in the asymmetric aziridination of unsaturated aldehydes and lead to the desired chiral products in high yields (up to 93 %) with enantiomeric excess values up to 92 %. The influence of the stereogenic centers at the sulfinyl sulfur atom and in the amine moiety on the stereochemical outcome of the title reaction is discussed. An efficient combination: Enantiomerically pure hetero-organic ligands, which bear a hydroxy moiety, a stereogenic sulfinyl group, and an enantiomeric amine moiety, are highly efficient in the asymmetric aziridination of unsaturated aldehydes to lead to the desired products in high yields (up to 93 %) and with enantiomeric excess values up to 92 %. Cbz=Carboxybenzyl.
Catalytic asymmetric aziridination of α,β-unsaturated aldehydes
Deiana, Luca,Dziedzic, Pawel,Zhao, Gui-Ling,Vesely, Jan,Ibrahem, Ismail,Rios, Ramon,Sun, Junliang,Cordova, Armando
supporting information; experimental part, p. 7904 - 7917 (2011/08/05)
The development, scope, and application of the highly enantioselective organocatalytic aziridination of α,β-unsaturated aldehydes is presented. The aminocatalytic azirdination of α,β-unsaturated aldehydes enables the asymmetric formation of β-formyl aziri
