131613-01-9Relevant academic research and scientific papers
SYNTHESIS OF (19e)-17Β-HYDROXY-3-OXOANDROST-4-EN-19-AL-19-(O-CARBOXYMETHYL)OXIME
Fajkos, Jan,Pouzar, Vladimir,Veres, Karel
, p. 2086 - 2094 (2007/10/02)
The title compound XIII was synthesized from epoxide I.Cleavage with zinc dust and Jones' oxidation under mild conditions afforded aldehyde V.Reaction with (O-carboxymethyl)hydroxylamine hemihydrochloride followed by methylation with diazomethane led to oxime X which on partial hydrolysis gave the 3-hydroxy derivative VIII.Its oxidation accompanied with a rearrangement of the double bond yielded ketone XVI which on hydrolysis afforded the desired hapten XIII.
