131614-91-0Relevant articles and documents
Partial racemization occurring in the hydroxylactonization of a δ,ε-Epoxy Amide
Enomoto, Masaru,Kuwahara, Shigefumi
, p. 2535 - 2537 (2013/01/09)
Acid-promoted hydroxylactonization of a δ,ε-epoxy amide took place via both 6-exo-tet and 7-endo-tet processes, causing a considerable degree of racemization of the resulting δ-hydroxyalkyl-δ-lactone.
LITHIATION OF BENZENE DERIVATIVES PROMOTED BY β-FUNCTIONALISED ALKYL GROUPS. ASYMMETRIC SYNTHESIS OF THE ISOCOUMARIN PORTION OF AI-77-B
Bertelli, Lucia,Fiaschi, Rita,Napolitano, Elio
, p. 669 - 672 (2007/10/02)
The title compound has been synthesized in five high-yielding steps from (2S,3R)-1,2-epoxy-5-methylhexan-1-ol, 12, prepared by Sharpless asymmetric epoxidation of allylic alcohols. The key step of the sequence was the clean metallation at position 2' of t