1316196-87-8

Basic information

• Product Name: 2-methoxy-N-(2-(2-oxo-2-(pyrimidin-2-ylamino)ethylthio)benzo[d]thiazol-6-yl)benzamide
• CAS NO: 1316196-87-8
• Molecular Weight: 451.53
• Mol File: 1316196-87-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-methoxy-N-(2-(2-oxo-2-(pyrimidin-2-ylamino)ethylthio)benzo[d]thiazol-6-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-N-(2-(2-oxo-2-(pyrimidin-2-ylamino)ethylthio)benzo[d]thiazol-6-yl)benzamide(1316196-87-8)
• EPA Substance Registry System: 2-methoxy-N-(2-(2-oxo-2-(pyrimidin-2-ylamino)ethylthio)benzo[d]thiazol-6-yl)benzamide(1316196-87-8)

Safety Data

• Hazardous Substances Data: 1316196-87-8(Hazardous Substances Data)

Upstream product

• 52687-97-5 2-chloro-N-(pyrimidin-2-yl)acetamide 
• 1316196-26-5 C₁₃H₁₁N₅OS₂ 
• 21615-34-9 2-Methoxybenzoyl chloride 

Relevant articles and documents

Synthesis and biological evaluation of novel benzothiazole-2-thiol derivatives as potential anticancer agents

A series of novel benzothiazole-2-thiol derivatives were synthesized and their structures determined by 1H-NMR, 13C-NMR and HRMS (ESI). The effects of all compounds on a panel of different types of human cancer cell lines were investigated. Among them, pyridinyl-2-amine linked benzothiazole-2-thiol compounds 7d, 7e, 7f and 7i exhibited potent and broad-spectrum inhibitory activities. Compound 7e displayed the most potent anticancer activity on SKRB-3 (IC50 = 1.2 nM), SW620 (IC50 = 4.3 nM), A549 (IC50 = 44 nM) and HepG2 (IC50 = 48 nM) and was found to induce apoptosis in HepG2 cancer cells.