13162-27-1

Basic information

• Product Name: 5-Pyrimidinamine,2,4-dichloro-6-methyl-
• Synonyms: Pyrimidine,5-amino-2,4-dichloro-6-methyl- (7CI,8CI);2,4-Dichloro-5-amino-6-methylpyrimidine;2,4-dichloro-6-methyl-pyrimidin-5-amine;5-Pyrimidinamine, 2,4-dichloro-6-methyl-
• CAS NO: 13162-27-1
• Molecular Formula: C₅H₅Cl₂N₃
• Molecular Weight: 178.0193
• Product Categories: Building Blocks;Pyrimidine
• Mol File: 13162-27-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 115-116.5℃
• Boiling Point: 281.6 °C at 760 mmHg
• Flash Point: 124.1 °C
• Appearance: /
• Density: 1.504 g/cm³
• Vapor Pressure: 0.00353mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -0.83±0.39(Predicted)
• CAS DataBase Reference: 5-Pyrimidinamine,2,4-dichloro-6-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinamine,2,4-dichloro-6-methyl-(13162-27-1)
• EPA Substance Registry System: 5-Pyrimidinamine,2,4-dichloro-6-methyl-(13162-27-1)

Safety Data

• Hazard Codes: Xi:
• Statements: 22-41
• Safety Statements: 26-39
• Hazardous Substances Data: 13162-27-1(Hazardous Substances Data)

Usage

General Description

5-Pyrimidinamine,2,4-dichloro-6-methyl- is a chemical compound with the molecular formula C6H5Cl2N3. It is an organic compound that belongs to the class of pyrimidines and is used in the synthesis of pharmaceuticals and agrochemicals. This chemical is also known as 2,4-dichloro-6-methylpyrimidin-5-amine and is commonly used as a building block in the production of various drugs and agricultural products. It is a white to light brown crystalline solid that is sparingly soluble in water and is primarily used in laboratory research and chemical synthesis. Overall, 5-Pyrimidinamine,2,4-dichloro-6-methyl- is a versatile chemical that has various applications in the pharmaceutical and agricultural industries.

InChI:InChI=1/C5H5Cl2N3/c1-2-3(8)4(6)10-5(7)9-2/h8H2,1H3

Upstream product

• 16632-21-6 5-nitro-6-methyluracil 
• 626-48-2 6-Methyluracil 
• 13162-26-0 2,4-dichloro-6-methyl-5-nitropyrimidine 

Downstream Products

• 633328-98-0 5-chloro-1H-pyrazolo[4,3-d]pyrimidine 

Relevant articles and documents

Synthesis and density functional theory study of [1,2,3]triazolo[4,5-d][1,2,4] triazolo[4,3-A]pyrimidine derivatives: A novel heterocyclic system

Several 3H-[1,2,3]triazolo[4,5-d][1,2,4]triazolo[4,3-A]pyrimidine derivatives of a novel ring system have been synthesised. The initial substitution of the 4-Cl function of 2,4-dichloro-6-methylpyrimidin-5-Amine with benzylamine followed by treatment with

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Synthesis of pyrimido[4′,5′:2,3][1,4]thiazepino[7,6-b]quinolines, derivatives of a novel ring system

Several derivatives of the novel pyrimido[4′,5′:2,3][1,4]thiazepino[7,6-b]quinoline ring system have been synthesized through cyclocondensation of 5-amino-6-methylpyrimidine-4-thiols 5a,b and 2-chloroquinoline-3-carbaldehydes 6a-c in the presence of K2 CO3 in DMF.

Photochemical synthesis method of heteroarylamine compounds

The invention provides a photochemical synthesis method of heteroarylamine compounds. The photochemical synthesis method comprises the following steps: S1, mixing raw materials including heteroaryl nitro compounds, a solvent and a photocatalyst to obtain a mixture; and S2, carrying out a photocatalytic reduction reaction on the mixture under an illumination condition to obtain a product system containing the heteroarylamine compounds. According to the photochemical synthesis method, photocatalytic reduction of various different heteroaryl nitro compounds is achieved under the illumination condition, and the high-yield heteroaryl amine compounds are obtained. The photocatalyst is an existing common catalyst, has no strict requirements on equipment and is easy to recover, and the safety riskof the heteroarylamine compound and the catalyst cost are reduced. Any metal reagent and reducing agent do not need to be added in the whole reaction process of photocatalysis, the reaction conversion rate is high, and post-treatment is simple and easy to operate, so the method is safer and more environmentally friendly.