1316335-63-3Relevant academic research and scientific papers
Asymmetric Aza-[3 + 3] annulation in the synthesis of indolizidines: An unexpected reversal of regiochemistry
Buchanan, Grant S.,Dai, Huifang,Hsung, Richard P.,Gerasyuto, Aleksey I.,Scheinebeck, Casi M.
, p. 4402 - 4405 (2011)
An enantioselective and diastereoselective aza-[3 + 3] annulation of pyrrolidine-based exo-cyclic vinylogous amides and urethanes with chiral vinyl iminium salts is described. This asymmetric annulation manifold is possible because of an unexpected regiochemical reversal whereby head-to-tail annulations dominated over the predicted head-to-head. It should find prevalent synthetic applications in the enantioselective synthesis of indolizidines.
