13164-96-0

Upstream product

• 7664-93-9 sulfuric acid 
• 103-71-9 phenyl isocyanate 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 62-53-3 aniline 
• 401638-30-0 C₁₅H₁₃ClN₂O₃ 
• 201230-82-2 carbon monoxide 
• 349406-24-2 2-nitro-4-chlorobenzanilide 
• 32315-10-9 bis(trichloromethyl) carbonate 

Relevant academic research and scientific papers

Specific inhibitors of puromycin-sensitive aminopeptidase with a 3-(halogenated phenyl)-2,4(1H,3H)-quinazolinedione skeleton

Specific puromycin-sensitive aminopeptidase (PSA) inhibitors with a 3-(halogenated phenyl)-2,4(1H,3H)-quinazolinedione skeleton were prepared and their structure-activity relationships were investigated. The nature (F, Cl or Br), number and position(s) of the halogen atom(s) introduced into the 3-phenyl group were concluded to be critical determinants of the inhibitory activity.

Metal and phosgene-free synthesis of 1H-quinazoline-2,4-diones by selenium-catalyzed carbonylation of o-nitrobenzamides

1H-Quinazoline-2,4-diones were efficiently synthesized by selenium-catalyzed carbonylation of o-nitrobenzamides under relatively mild conditions. In situ-generated carbonyl selenide (SeCO) is proposed to initiate the catalytic carbonylation. Thus, a concise transition metal and phosgene-free synthetic route to potentially bioactive-substituted 1H-quinazoline-2,4-dione derivatives has been developed.

An efficient synthesis of quinazoline-2,4-dione derivatives with the aid of a low-valent titanium reagent

A facile synthetic method using low-valent titanium reagent (TiCl4/Zn system) to promote the novel reductive cyclization of 2-nitrobenzamides and triphosgene is described. Sequentially, a series of quinazoline-2,4-diones were synthesized in goo

Process for the preparation of quinazoline-2,4-diones

Quinazoline-2,4-diones are obtained in high yields and purities by reacting anthranilic acids with isocyanates and then, without isolation of the urea formed as intermediate, treating the reaction mixture with acid.