131670-17-2

Upstream product

• 131653-62-8 2,2-dimethyl-N-(4-iodo-2-methoxy-3-pyridyl)propanamide 
• 98-80-6 phenylboronic acid 
• 125867-19-8 N-(2-methoxy-3-pyridyl)-2,2-dimethylpropanamide 

Downstream Products

• 142643-49-0 2-(4-phenyl-3-pivaloylamino)pyridyltriflate 
• 142643-45-6 2-<2-(4-phenyl-3-pivaloylamino)pyridyl>quinoline 
• 142643-48-9 7-phenyl-2-tertiobutyloxazolo<5,4-b>pyridine 
• 142643-46-7 4-phenyl-3-pivaloylamino-2-(1H)pyridone 

Relevant academic research and scientific papers

Metallation in connection with cross-coupling reactions. Coupling of hindered aryls for the synthesis of 4-phenylpyridines as part of Streptonigrin and Lavendamycin analogues

The synthesis of the C-D ring system of Streptonigrin and Lavendamycln alkaloid analogues by cross-coupling under Suzuki's conditions has been studied. Steric hindrance is the main problem. It has been solved either by using strong bases or working in a sealed tube under pressure.

Convergent synthesis of the streptonigrin alkaloid skeleton. Directed orthometalation connection to aryl-aryl cross-coupling

A convergent synthesis of 2-[2-(4-phenyl-3-pivaloylamino) pyridyl]quinolines, the streptonigrin alkaloid skeleton, is reported. The methodology involves independent elaboration of the three main building blocks by metalation and two coupling reactions cat

Synthesis of 3-Amino-4-phenylpyridines: a Novel Strategy for the Preparation of CD Ring Models of Streptonigrin

An efficient synthesis of 3-amino-4-phenylpyridine derivatives is reported. 3-Pivaloylaminopyridines were lithiated by butyl-lithium before reaction with iodine as electrophile to afford 4-iodo-3-pivaloylaminopyridines.Cross-coupling of the latter with su