131674-44-7

Upstream product

• 109-09-1 2-chloropyridine 
• 135-02-4 ortho-anisaldehyde 
• 52200-48-3 3-bromo-2-chloropyridine 

Downstream Products

• 86580-60-1 1-(2-chloropyridin-3-yl)-(2-methoxyphenyl)methanone 
• 131674-49-2 (methoxyphenyl)-(2'methoxypyridin-3'-yl)methanone 
• 79574-80-4 (2-aminopyridin-3-yl)-(2-methoxyphenyl)methanone 

Relevant academic research and scientific papers

New syntheses of substituted pyridines via bromine-magnesium exchange

Bromine-magnesium exchange using iPrMgCl in THF at room temperature on 2-, 3- and 4-bromopyridines allowed the synthesis of various functionalized pyridines. The methodology was successfully used for the synthesis of 4- azaxanthone. Moreover, single exchange reactions observed on 2,6-, 3,5-, 2,3- and 2,5-dibromopyridines, with complete regioselectivity in the case of 2,3- and 2,5-dibromopyridines, afforded substituted bromopyridines, which were then involved in a second exchange step to provide difunctionalized pyridines. (C) 2000 Elsevier Science Ltd.

Improved Synthesis of 2,3-Disubstituted Pyridines by Metallation of 2-Chloropyridine: a Convenient Route to Fused Polyheterocycles

Chemoselective directed metallation of 2-chloropyridine allows the synthesis of 2-substituted 3-carbonylated pyridines, advantage being taken of the metallation ortho-directing effect of the halogen, as well as its reactivity towards nucleophiles.Thus (2-chloro-, 2-methoxy-, and 2-amino-3-pyridyl)-ethanones and -arylmethanones as well as carbaldehydes have been prepared.Some of these ortho-disubstituted intermediates have been readily cyclized to fused polyheterocycles such as naphthiridines and aza-analoges of coumarins, xanthones, and acridones.