1316754-28-5

Basic information

• Product Name: ethyl 3-(m-tolyl)-1H-pyrazole-5-carboxylate
• CAS NO: 1316754-28-5
• Molecular Weight: 230.266
• Mol File: 1316754-28-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 3-(m-tolyl)-1H-pyrazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(m-tolyl)-1H-pyrazole-5-carboxylate(1316754-28-5)
• EPA Substance Registry System: ethyl 3-(m-tolyl)-1H-pyrazole-5-carboxylate(1316754-28-5)

Safety Data

• Hazardous Substances Data: 1316754-28-5(Hazardous Substances Data)

Upstream product

• 585-74-0 3-Methylacetophenone 
• 741286-41-9 ethyl 2,4-dioxo-4-m-tolylbutanoate 

Downstream Products

• 1257427-49-8 1-[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]-3-m-tolyl-1H-pyrazole-5-carboxylic acid 
• 1316754-37-6 C₁₁H₁₀N₂O₂ 
• 1316754-43-4 C₂₄H₂₉N₅O 

Relevant articles and documents

PIKFYVE KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) as well as their use for treating diseases and disorders associated with PIKfyve.

Synthesis and cytotoxicity evaluation of 1-[3-(9H-carbazol-4-yloxy)-2- hydroxypropyl]-3-aryl-1H-pyrazole-5-carboxylic acid derivatives

Several novel molecules, 1-(3′-(9H-carbazol-4-yloxy)-2′- hydroxypropyl)-3-aryl-1H-pyrazole-5-carboxylic acid derivatives 3a-g were synthesized and screened to evaluate their cytotoxicity against cancer cells in vitro. The compounds 3a-g has been prepared by the reaction of ethyl 3-aryl-1H-pyrazole-5-carboxylate with 4-oxiranylmethoxy-9H-carbazole in moderate to excellent yields. The cytotoxicity of synthesized compounds was evaluated by a SRB (sulforhodamine B) assay against cancer cell such as SK-N-SH human neuroblastoma (NB), human A549 lung carcinoma, human breast cancer MCF-7 cell lines. The results showed that seven compounds can suppress SK-N-SH tumor cancer cell growth. Among them, compound 3d was the most effective small molecule in inhibiting SK-N-SH cell growth.