Cas 1316754-28-5,ethyl 3-(m-tolyl)-1H-pyrazole-5-carboxylate

1316754-28-5

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Basic information

Product Name: ethyl 3-(m-tolyl)-1H-pyrazole-5-carboxylate
Synonyms:
CAS NO:1316754-28-5
Molecular Formula:
Molecular Weight: 230.266
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: ethyl 3-(m-tolyl)-1H-pyrazole-5-carboxylate(CAS DataBase Reference)
NIST Chemistry Reference: ethyl 3-(m-tolyl)-1H-pyrazole-5-carboxylate(1316754-28-5)
EPA Substance Registry System: ethyl 3-(m-tolyl)-1H-pyrazole-5-carboxylate(1316754-28-5)

Safety Data

Hazard Codes: N/A
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Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
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Hazardous Substances Data: 1316754-28-5(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1316754-28-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,1,6,7,5 and 4 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1316754-28:
(9*1)+(8*3)+(7*1)+(6*6)+(5*7)+(4*5)+(3*4)+(2*2)+(1*8)=155
155 % 10 = 5
So 1316754-28-5 is a valid CAS Registry Number.

1316754-28-5Upstream product

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1316754-28-5Relevant academic research and scientific papers

PIKFYVE KINASE INHIBITORS

-

, (2021/08/20)

The present invention relates to compounds useful as inhibitors of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) as well as their use for treating diseases and disorders associated with PIKfyve.

Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4- phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives

Nagarapu, Lingaiah,Mateti, Jhansi,Gaikwad, Hanmant K.,Bantu, Rajashaker,Sheeba Rani,Prameela Subhashini

, p. 4138 - 4140 (2011/08/06)

A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5- carboxamide derivatives were synthesized and investigated their anti-inflammatory activities using carrageenan-induced rat paw edema model in vivo. All the synthesized compounds were found to be potent anti-inflammatory agents.

Synthesis and cytotoxicity evaluation of 1-[3-(9H-carbazol-4-yloxy)-2- hydroxypropyl]-3-aryl-1H-pyrazole-5-carboxylic acid derivatives

Nagarapu, Lingaiah,Gaikwad, Hanmant K.,Sarikonda, Kartheeka,Mateti, Jhansi,Bantu, Rajashaker,Raghu,Manda, Krishna Madhuri,Kalvendi, Shasi Vardhan

experimental part, p. 4720 - 4725 (2010/11/16)

Several novel molecules, 1-(3′-(9H-carbazol-4-yloxy)-2′- hydroxypropyl)-3-aryl-1H-pyrazole-5-carboxylic acid derivatives 3a-g were synthesized and screened to evaluate their cytotoxicity against cancer cells in vitro. The compounds 3a-g has been prepared by the reaction of ethyl 3-aryl-1H-pyrazole-5-carboxylate with 4-oxiranylmethoxy-9H-carbazole in moderate to excellent yields. The cytotoxicity of synthesized compounds was evaluated by a SRB (sulforhodamine B) assay against cancer cell such as SK-N-SH human neuroblastoma (NB), human A549 lung carcinoma, human breast cancer MCF-7 cell lines. The results showed that seven compounds can suppress SK-N-SH tumor cancer cell growth. Among them, compound 3d was the most effective small molecule in inhibiting SK-N-SH cell growth.

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