1316761-63-3Relevant academic research and scientific papers
Identification of novel PI3K inhibitors through a scaffold hopping strategy
Martínez González, Sonia,Hernández, Ana Isabel,álvarez, Rosa María,Rodríguez, Antonio,Ramos-Lima, Francisco,Bischoff, James R.,Albarrán, María Isabel,Cebriá, Antonio,Hernández-Encinas, Elena,García-Arocha, Jennifer,Cebrián, David,Blanco-Aparicio, Carmen,Pastor, Joaquín
, p. 4794 - 4799 (2017/10/12)
A scaffold hopping strategy, including intellectual property availability assessment, was successfully applied for the discovery of novel PI3K inhibitors. Compounds were designed based on the chemical structure of the lead compound ETP-46321, a potent PI3
INHIBITORS OF PI3 KINASE
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Page/Page column 124, (2011/08/08)
There is provided compounds of formula (I), wherein A1, A4, A4a, A5, B1, B1a, B2, B2a, B3, B3a, B4, B4a and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PI3-K and/or mTOR) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.
