131690-57-8

Basic information

• Product Name: (R)-3-AMINO-3-(4-METHOXY-PHENYL)-PROPIONIC ACID
• Synonyms: (R)-BETA-(P-METHOXYPHENYL)ALANINE;(R)-B-(P-METHOXYPHENYL)-B-ALANINE;(R)-3-AMINO-3-(4-METHOXY-PHENYL)-PROPIONIC ACID;L-BETA-HOMO(4-METHOXYPHENYL)GLYCINE;H-PHG(4-OME)-(C*CH2)OH;H-D-BETA-PHE(4-OME)-OH;(R)--(p-Methoxyphenyl)alanine;(R)-3-(P-METHOXYPHENYL)-BETA-ALANINE
• CAS NO: 131690-57-8
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.22
• Mol File: 131690-57-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 356.391 °C at 760 mmHg
• Flash Point: 169.339 °C
• Appearance: /
• Density: 1.206 g/cm³
• Vapor Pressure: 1.07E-05mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: (R)-3-AMINO-3-(4-METHOXY-PHENYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-AMINO-3-(4-METHOXY-PHENYL)-PROPIONIC ACID(131690-57-8)
• EPA Substance Registry System: (R)-3-AMINO-3-(4-METHOXY-PHENYL)-PROPIONIC ACID(131690-57-8)

Safety Data

• Hazardous Substances Data: 131690-57-8(Hazardous Substances Data)

Usage

General Description

(R)-3-AMINO-3-(4-METHOXY-PHENYL)-PROPIONIC ACID is a chemical compound that is also known as L-3-(4-methoxyphenyl)alanine. It is an amino acid derivative that contains both an amino group and a carboxylic acid group. (R)-3-AMINO-3-(4-METHOXY-PHENYL)-PROPIONIC ACID is commonly used in the pharmaceutical industry as a building block for the synthesis of various pharmaceuticals and bioactive molecules. It is also used in research and development for the study of neurobiology and the central nervous system. Additionally, (R)-3-AMINO-3-(4-METHOXY-PHENYL)-PROPIONIC ACID is known to exhibit analgesic and anti-inflammatory properties, making it potentially useful for the treatment of pain and inflammatory conditions.

InChI:InChI=1/C10H13NO3/c1-14-8-4-2-7(3-5-8)9(11)6-10(12)13/h2-5,9H,6,11H2,1H3,(H,12,13)/t9-/m1/s1

Upstream product

• 873326-22-8 tert-butyl (3R)-3-amino-3-(4-methoxyphenyl)propanoate 
• 696-62-8 para-iodoanisole 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 5678-45-5 3-amino-3-(4-methoxyphenyl)propionic acid 
• 1045712-38-6 C₃₂H₃₃NO₃ 
• 135383-24-3 5-Acetoxy-3-(4-methoxyphenyl)-N-(R)-α-methylbenzylisoxazolidine 
• 135383-46-9 5-Chloro-3-(4-methoxy-phenyl)-2-((R)-1-phenyl-ethyl)-isoxazolidine-5-carbonitrile 
• 135383-33-4 N-(R)-α-Methylbenzyl-3-(4-methoxyphenyl)isoxazolidin-5-ol 
• 135383-13-0 N-(p-Mthoxybenzylidene)<(R)-(-)-α-methylbenzyl>amine N-oxide 
• 131791-83-8 (S)-2-tert-Butyl-6-(4-methoxyphenyl)-5,6-dihydro-4-(1H)-pyrimidinone 
• 53484-52-9 tert-butyl (E)-3-(4-methoxyphenyl)prop-2-enoate 
• 951174-19-9 tert-butyl (3R,αS)-3-[N-benzyl-N-(α-methylbenzyl)-amino]-3-(4'-methoxyphenyl)propanoate 
• 6230-11-1 O-Methyltyrosine 

Downstream Products

• 134781-82-1 (R)-β-Tyrosine Methyl Ether Methyl Ester hydrochloride 
• 119717-37-2 jasplakinolide 
• 131791-80-5 N-Boc-(S)-alanyl-N-methyl-2-bromo-(R)-tryptophanyl-O-methyl-(R)-β-tyrosine Methyl Ester 
• 134781-91-2 (R)-3-[(R)-2-[((S)-2-Amino-propionyl)-methyl-amino]-3-(2-bromo-1H-indol-3-yl)-propionylamino]-3-(4-methoxy-phenyl)-propionic acid methyl ester 
• 161925-59-3 jaspamide Z₁ 
• 134815-49-9 (E)-(2S,6R,8S)-8-<(tert-Butyldimethylsilyl)oxy>-2,4,6-trimethyl-4-nonenoyl-(S)-alanyl-N-methyl-2-bromo-(R)-tryptophanyl-O-methyl-(R)-β-tyrosine Methyl Ester 
• 511272-33-6 C₂₅H₂₃NO₅ 

Relevant articles and documents

β-styryl- and β-aryl-β-alanine products of phenylalanine aminomutase catalysis

The substrate specificity of a Taxus-derived phenylalanine aminomutase (PAM) was investigated, and the enzyme was found to catalyze the conversion of variously substituted vinyl- and aryl-S-∞-alanines to corresponding β-amino acids. This study shows the b

Enantioselective acylation of β-phenylalanine acid and its derivatives catalyzed by penicillin G acylase from alcaligenes faecalis

This study developed a simple, efficient method for producing racemic β-phenylalanine acid (BPA) and its derivatives via the enantioselective acylation catalyzed by the penicillin G acylase from Alcaligenes faecalis (Af-PGA). When the reaction was run at 25°C and pH 10 in an aqueous medium containing phenylacetamide and BPA in a molar ratio of 2:1, 8 U/mL enzyme and 0.1 M BPA, the maximum BPA conversion efficiency at 40 min only reached 36.1%, which, however, increased to 42.9% as the pH value and the molar ratio of phenylacetamide to BPA were elevated to 11 and 3:1, respectively. Under the relatively optimum reaction conditions, the maximum conversion efficiencies of BPA derivatives all reached about 50% in a relatively short reaction time (45-90 min). The enantiomeric excess value of product (eep) and enantiomeric excess value of substrate (ees) were all above 98% and 95%, respectively. These results suggest that the method established in this study is practical, effective, and environmentally benign and may be applied to industrial production of enantiomerically pure BPA and its derivatives.

Phenylalanine aminomutase-catalyzed addition of ammonia to substituted cinnamic acids: A route to enantiopure α- and β-amino acids

(Chemical Equation Presented) An approach is described for the synthesis of aromatic α- and β-amino acids that uses phenylalanine aminomutase to catalyze a highly enantioselective addition of ammonia to substituted cinnamic acids. The reaction has a broad scope and yields substituted α- and β-phenylalanines with excellent enantiomeric excess. The regioselectivity of the conversion is determined by substituents present at the aromatic ring. A box model for the enzyme active site is proposed, derived from the influence of the hydrophobicity of substituents on the enzyme affinity toward various substrates.