131701-06-9

Basic information

• Product Name: (2S,3S)-3-Hydroxy-2-methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one
• Synonyms: (2S,3S)-3-Hydroxy-2-methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one
• CAS NO: 131701-06-9
• Molecular Weight: 345.419
• Mol File: 131701-06-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3S)-3-Hydroxy-2-methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-3-Hydroxy-2-methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one(131701-06-9)
• EPA Substance Registry System: (2S,3S)-3-Hydroxy-2-methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one(131701-06-9)

Safety Data

• Hazardous Substances Data: 131701-06-9(Hazardous Substances Data)

Upstream product

• 131700-89-5 1-((R)-3-Methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-propan-1-one 
• 130973-53-4 (R)-3-methyl-2,3-dihydrobenzo[d]isothiazoline 1,1-dioxide 
• 131700-99-7 (S)-2-Methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propane-1,3-dione 

Downstream Products

• 76549-02-5 (-)-(2S,3S)-3-hydroxy-2-methyl-3-phenylpropanoic acid 
• 130973-53-4 (R)-3-methyl-2,3-dihydrobenzo[d]isothiazoline 1,1-dioxide 
• 131700-98-6 (S)-2-(Benzhydrylidene-amino)-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one 
• 131700-92-0 2-(Benzhydrylidene-amino)-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-ethanone 

Relevant articles and documents

CHIRAL TOLUENE-2,α-SULTAM AUXILIARIES: ASYMMETRIC ALKYLATIONS, ACYLATIONS AND ALDOLIZATIONS OF N-ACYL DERIVATIVES

Successive treatment of (R)-N-acylsultams 4 with NHDMS/alkyl halides or NHDMS/acyl chlorides provides alkylated or acylated products 6 or 7.Diastereoselective reductions of 7 with Zn(BH4)2 or NaHB(sBu)3 gives "syn"- or "anti"-aldols 8 or 9.Reaction of 4 with BEt3/TfOH/EtN(iPr)2 followed by addition of aromatic or aliphatic aldehydes affords diastereomerically pure "syn"-aldols 10.Non-destructive removal of auxiliary 3 from 6, 8, 9 and 10 yields enantiomerically pure products 12 to 16.