131719-87-4

Upstream product

• 917-57-7 vinyllithium 
• 156414-57-2 tert-Butyl-[(1R,2R,4S)-2-methoxy-4-((R)-(R)-2-oxiranyl-propyl)-cyclohexyloxy]-dimethyl-silane 
• 131758-34-4 C₆₃H₁₀₇NO₁₃Si₂ 
• 131719-83-0 C₄₁H₆₉NO₁₂Si 
• 131719-85-2 (3E,6E)-(R)-9-[(1S,3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-4,8-dimethyl-5-oxo-nona-3,6-dienoic acid methyl ester 
• 157837-39-3 Methanesulfonic acid (1S,2R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2-methyl-propyl ester 
• 157837-32-6 (2S,3R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butan-2-ol 
• 186449-19-4 (1R,2R,4S)-2-Methoxy-4-((R)-(R)-2-oxiranyl-propyl)-cyclohexanol 
• 127258-23-5 (1R,2R,4R)-4-<(phenylsulfonyl)methyl>-2-methoxy-1-<oxy>cyclohexane 
• 131719-86-3 (R)-3-[(1S,3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-2-methyl-propionaldehyde 
• 53123-88-9 (22E,24E,26E,27E,29R,30S,31R,32R,34S,36S,38S,39S,40S,41R,50R)-40,50-dihydroxy-39-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl]-1-methyl-ethyl]-38,41-dimethoxy-29,30,31,32,42,43-hexamethyl-60,61-dioxa-51-azatricyclohexatriaconta-22,24,26⁽⁴²⁾,27⁽⁴³⁾-tetraene-44,45,46,47,48-pentone 
• 131758-35-5 C₄₄H₇₃NO₁₃Si 

Downstream Products

• 137298-96-5 [(1R,2R,4S)-4-((2R,3S)-3-Benzyloxymethoxy-2-methyl-4-oxiranyl-butyl)-2-methoxy-cyclohexyloxy]-tert-butyl-dimethyl-silane 
• 145411-59-2 (2R,3S,5S)-3-Benzyloxymethoxy-1-[(1S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-2-methyl-undec-10-en-5-ol 
• 145411-59-2 (2R,3S,5R)-3-Benzyloxymethoxy-1-[(1S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-2-methyl-undec-10-en-5-ol 
• 137299-02-6 (1R,9S,12S,14S,24R,27R)-1,14-Dihydroxy-12-[(R)-2-((1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-ethyl]-27-methyl-11,28-dioxa-4-aza-tricyclo[22.3.1.0^4,9]octacosane-2,3,10,20-tetraone 
• 137298-98-7 (7S,9S,10R)-9-Benzyloxymethoxy-7-(tert-butyl-dimethyl-silanyloxy)-11-[(1S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-10-methyl-undecanoic acid methyl ester 
• 137298-97-6 ((1S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-{(R)-2-[(1S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl}-non-8-enyloxymethoxymethyl)-benzene 

Relevant academic research and scientific papers

Rapamycin synthetic studies. 1. Construction of the C(27)-C(42) subunit

A convergent synthetic approach to the C(27)-C(42) fragment of the immunosuppressive macrocycle rapamycin is described.

DEGRADATIVE STUDIES ON THE TRICARBONYL CONTAINING MACROLIDE RAPAMYCIN

The degradation of rapamycin, a tricarbonyl containing macrolide similar in structure to the potent immunosuppressant FK-506, is described.Three principal fragments are obtained in this process that should have utility in the semi-synthesis of FK-506 and