131725-47-8

Basic information

• Product Name: (+-)-3-amino-5-methyl-hexanoic acid
• Synonyms: 3-AMINO-5-METHYLHEXANOIC ACID
• CAS NO: 131725-47-8
• Molecular Formula: C7H15NO2
• Molecular Weight: 145.2
• Mol File: 131725-47-8.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (+-)-3-amino-5-methyl-hexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (+-)-3-amino-5-methyl-hexanoic acid(131725-47-8)
• EPA Substance Registry System: (+-)-3-amino-5-methyl-hexanoic acid(131725-47-8)

Safety Data

• Hazardous Substances Data: 131725-47-8(Hazardous Substances Data)

Usage

General Description

"(+-)-3-amino-5-methyl-hexanoic acid" is a chemical compound with the molecular formula C7H15NO2. It is a derivative of the amino acid valine, with a single methyl group substitution at the 5th carbon. (+-)-3-amino-5-methyl-hexanoic acid plays a critical role in the biosynthesis of biologically active molecules and is used in the pharmaceutical industry as a precursor for the synthesis of various drugs and therapeutic agents. It is also a valuable building block in the production of peptides and proteins. The compound's unique structure and properties make it an important component in the formulation of pharmaceutical products and research into new drug development.

Upstream product

• 2018-66-8 Z-Leu-OH 
• 193887-44-4 (S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-methylhexanoic acid 
• 3653-34-7 3-amino-5-methylhexanoic acid 
• 136918-14-4 phthalimide 
• 51615-30-6 diethyl 2-(3-methylbutylidene)malonate 
• 22818-42-4 (3S)-N-(4-methylbenzene)-1-sulfonoamido-5-methylhexanoic acid 
• 146398-16-5 (R)-tert-butyl 3-<(benzyloxycarbonyl)amino>-5-methylhexanoate 
• 590-86-3 isovaleraldehyde 
• 138877-97-1 tert-butyl (E)-5-methyl-hex-2-enoate 
• 951174-29-1 tert-butyl (3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)-5-methylhexanoate 
• 166023-29-6 1,1-dimethylethyl (3R)-3-amino-5-methylhexanoate 
• 75513-56-3 (E)-methyl 5-methyl-2-hexenoate 
• 118247-77-1 3-<(benzyloxycarbonyl)amino>-5-methylhexanoic acid 
• 141-82-2 malonic acid 

Downstream Products

• 109510-47-6 (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methylhexanoic acid 
• 90726-94-6 (S)-3-amino-5-methyl-hexanoic acid ethyl ester 
• 107417-86-7 (S)-3-benzyl-6-isobutyl-dihydro-pyrimidine-2,4-dione 
• 101739-99-5 (S)-3-(N'-benzyl-ureido)-5-methyl-hexanoic acid ethyl ester 
• 101270-20-6 (S)-5-methyl-3-(N'-phenyl-ureido)-hexanoic acid ethyl ester 
• 22818-43-5 (S)-3-amino-5-methylhexanoic acid 
• 1311254-63-3 (R/S)-3-(benzyloxycarbonylamino)-5-methylhexanoic acid 
• 138165-75-0 3-(tert-butoxycarbonylamino)-5-methylhexanoic acid 
• 118247-68-0 N-Benzyloxycarbonyl-L-Homoleucine 
• 78175-30-1 (S)-3-(2,4-Dinitro-phenylamino)-5-methyl-hexanoic acid 
• 146398-18-7 3-<(tert-butyloxycarbonyl)amino>-5-methylhexanoic acid 
• 138165-75-0 N-Boc-L-β-homoleucine 

Relevant articles and documents

Preparation method of 3-aminopropanol or 3-aminopropionic acid derivative

The invention provides a preparation method of an optically active 3-aminopropanol or 3-aminopropionic acid derivative, and belongs to the technical field of organic synthesis. A compound having a structure as shown in a formula II and a formula III is used as a raw material, and the optically active 3-aminopropanol or 3-aminopropionic acid derivative is obtained through four basic steps, namely dehydration condensation, hydrogenation reduction, reduction and hydrolysis. The raw materials adopted in the preparation method are easy to obtain and low in cost; as a chiral phosphine-transitional metal catalyst is used in the hydrogenation reduction reaction, the optically active 3-aminopropanol or 3-aminopropionic acid derivative is efficient, high in selectivity, low in cost and suitable forlarge-scale production. Compared with existing chemical resolution and chiral introduction, the asymmetric hydrogenation synthesis method provided by the invention only produces one chiral product, ishigh in yield, and has relatively high advantages in economy and raw material utilization rate.

METHOD FOR OBTAINING OPTICALLY PURE AMINO ACIDS

This invention relates to a method for obtaining optically pure amino acids, including optical resolution and optical conversion. This method significantly shortens the time taken for optical transformation, and enables the repeated use of an organic solution containing a enantioselective receptor, to thereby obtain optically pure amino acids in a simple and remarkably efficient manner, and to enable the very economical mass production of optically pure amino acids.

Thermal cleavage of the Fmoc protection group

The Fmoc protection group is among the most commonly used protection groups for the amino function. A fast method for the thermal deavage of this protection group under base-free conditions without the need for dibenzofulvene scavengers is presented. The advantages of this method include straightforward testability by means of a simple high-temperature NMR experiment, usually high yields, and good selectivity towards the BOC protection group and t-butyl ethers.