131730-25-1

Basic information

• Product Name: Toluene-4-sulfonate3-[5-(2-methyl-[1,3]dioxolan-4-ylmethoxycarbonyl)-pentyl]-thiazol-3-ium;
• CAS NO: 131730-25-1
• Molecular Weight: 471.596
• Mol File: 131730-25-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Toluene-4-sulfonate3-[5-(2-methyl-[1,3]dioxolan-4-ylmethoxycarbonyl)-pentyl]-thiazol-3-ium;(CAS DataBase Reference)
• NIST Chemistry Reference: Toluene-4-sulfonate3-[5-(2-methyl-[1,3]dioxolan-4-ylmethoxycarbonyl)-pentyl]-thiazol-3-ium;(131730-25-1)
• EPA Substance Registry System: Toluene-4-sulfonate3-[5-(2-methyl-[1,3]dioxolan-4-ylmethoxycarbonyl)-pentyl]-thiazol-3-ium;(131730-25-1)

Safety Data

• Hazardous Substances Data: 131730-25-1(Hazardous Substances Data)

Upstream product

• 288-47-1 1,3-thiazole 
• 123545-81-3 Toluene-4-sulfonic acid 5-chlorocarbonyl-pentyl ester 

Relevant articles and documents

Disubstituted tetrahydrofurans and dioxolanes as PAF antagonists

A new series of disubstituted tetrahydrofuran and dioxolane derivatives were prepared and evaluated for their PAF antagonist activity in the PAF-induced in vitro platelet-aggregation and in vivo hypotension tests. Several of these compounds exhibited more potent activity than the structurally related 2-[N-acetyl-N-[[[[2-methoxy-3-[(octadecylcarbamoyl)oxy]propoxy] carbonyl]amino]methyl]-1-ethylpyridinium chloride (CV-6209, 3) in the in vitro assay, whereas all showed less potency in the in vivo test. The role of both the substituent nature and the placement and number of oxygen atoms in the ring are discussed. A qualitative SAR study was carried out on these nuclei.