131733-64-7Relevant academic research and scientific papers
Synthesis, conformational analysis and molecular docking studies on three novel dihydropyrimidine derivatives
Sallum, Lóide O.,Vaz, Wesley F.,Borges, Nádia M.,de Campos, Carlos E.M.,Bortoluzzi, Adailton J.,Franco, Chris H.J.,Ramos, Luciana M.,Napolitano, Hamilton B.
, p. 274 - 287 (2019)
The dihydropyrimidine (DHPM)derivatives I, II and III were synthesized through Biginelli reaction and characterized by X-ray diffraction and vibrational spectroscopic analyses (Raman and FTIR), whereas a conformational study was conducted. The results sho
Dihydropyrimidones: A ligands urease recognition study and mechanistic insight through in vitro and in silico approach
Khan, Farman Ali,Shamim, Shahbaz,Ullah, Nisar,Lodhi, Muhammad Arif,Khan, Khalid Mohammed,Kanwal,Ali, Farman,Afridi, Sahib Gul,Perveen, Shahnaz,Khan, Ajmal
, p. 120 - 132 (2020/10/12)
Scaffold varied dihydropyrimidone derivatives 1–20 were evaluated for their selective urease inhibitory kinetics potential. Compounds 1, 2, 3, 4, 5, 6, and 12 were found to be the most promising urease inhibitors and showed the inhibition (Ki v
Exploiting silver trifluoromethanesulfonate as efficient and reusable catalyst for the synthesis of dihydropyrimidine derivatives under different reaction environments
Roy, Dipak Kumar,Tamuli, Kashyap Jyoti,Bordoloi, Manobjyoti
, p. 3313 - 3323 (2019/11/03)
Different results were generated under different reaction conditions for the multicomponent reactions. Herein, an efficiently improved and mild protocol for the synthesis of dihydropyrimidine derivatives using cheap silver trifluoromethanesulfonate (CFsu
Structure based medicinal chemistry-driven strategy to design substituted dihydropyrimidines as potential antileishmanial agents
Rashid, Umer,Sultana, Riffat,Shaheen, Nargis,Hassan, Syed Fahad,Yaqoob, Farhana,Ahmad, Muhammad Jawad,Iftikhar, Fatima,Sultana, Nighat,Asghar, Saba,Yasinzai, Masoom,Ansari, Farzana Latif,Qureshi, Naveeda Akhter
, p. 230 - 244 (2016/04/05)
In an attempt to explore novel and more potent antileishmanial compounds to diversify the current inhibitors, we pursued a medicinal chemistry-driven strategy to synthesize novel scaffolds with common pharmacophoric features of dihydropyrimidine and chalcone as current investigational antileishmanial compounds. Based on the reported X-ray structure of Pteridine reductase 1 (PTR1) from Leishmania major, we have designed a number of dihydropyrimidine-based derivatives to make specific interactions in PTR1 active site. Our lead compound 8i has shown potent in vitro antileishmanial activity against promastigotes of L. Major and Leishmania donovani with IC50 value of 0.47 1/4g/ml and 1.5 1/4g/ml respectively. The excellent in vitro activity conclusively revealed that our lead compound is efficient enough to eradicate both visceral and topical leishmaniasis. In addition, docking analysis and in silico ADMET predictions were also carried out. Predicted molecular properties supported our experimental analysis that these compounds have potential to eradicate both visceral and topical leishmaniasis.
General solvent-free ionic liquid catalyzed C-N/C-C coupled cyclization to diverse dihydropyrimidinones and new organic materials: Langmuir-Blodgett film study
Majumdar, Swapan,De, Jhinuk,Pal, Ajitesh,Ghosh, Indra,Nath, Ranendu K.,Chowdhury, Sandip,Roy, Dipanwita,Maiti, Dilip K.
, p. 24681 - 24686 (2015/03/30)
An ionic liquid catalyzed dual C-N/C-C coupled cyclization of a three component assembly is demonstrated to access 3,4-dihydropyrimidin-2(1H)-one (DHPM) analogues under solvent-free green conditions. Innovative new organic materials are introduced with pu
One-pot synthesis of 3,4-dihydro-2(H)-pyrimidinones catalyzed by reusable acidic choline-based ionic liquids
Zhu, Anlian,Li, Qianqian,Li, Lingjun,Wang, Jianji
, p. 463 - 468 (2013/08/23)
A series of choline-based ionic liquids (CIL) have been synthesized in this work. The results suggested that both the cations and the anions have significant influences on their properties such as thermostabilities, acidities and their performances for the synthesis of 3,4-dihydro-2(H)-pyrimidinones. The optimized catalytic system based on the CIL [DMEA][HSO4] for the Biginelli reactions benefits from the wide substrates tolerance, benign reaction conditions, easy work-up procedures, and the feasible reusability of the ionic liquid. Graphical Abstract: The thermostabilities, acidities, and the catalytic activities for the Biginelli reactions are all follows the sequence of [DMEA][HSO4] > [Choline] [HSO4] > [DMEA][H 2PO4] > [Choline] [H2PO4][Figure not available: see fulltext.].
Ultrasound-mediated synthesis of 3,4-dihydropyrimidin-2-(1H)-ones (or Thiones) with NaHSO4·H 2O
Dilmaghani, Karim Akbari,Zeynizadeh, Behzad,Amirpoor, Maryam
, p. 1634 - 1642 (2013/10/21)
A fast and efficient Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)- ones (or thiones) by the reaction of aromatic aldehydes, β-dicarbonyls, and urea/thiourea using NaHSO4·H2O/ultrasound system is presented. The reactions were ca
The biginelli reaction with an imidazolium-tagged recyclable iron catalyst: Kinetics, mechanism, and antitumoral activity
Ramos, Luciana M.,Guido, Bruna C.,Nobrega, Catharine C.,Corrêa, José R.,Silva, Rafael G.,De Oliveira, Heibbe C. B.,Gomes, Alexandre F.,Gozzo, Fábio C.,Neto, Brenno A. D.
supporting information, p. 4156 - 4168 (2013/05/08)
The present work describes the synthesis, characterization, and application of a new ion-tagged iron catalyst. The catalyst was employed in the Biginelli reaction with impressive performance. High yields have been achieved when the reaction was carried ou
Chromic(III) sulfamate as a versatile catalyst for organic synthesis
Liu, Qing,Li, Zhen
experimental part, p. 3208 - 3210 (2012/02/03)
Chromic sulfamate was synthesized and used as catalyst for the first time in various organic reactions such as the transformation of aldehydes or ketones and indole to bis(indolyl)methanes, the transformation of aldehydes and acetic anhydride to 1,1-diacetates and Biginelli reaction. The advantages of the chromic sulfamate are ease of preparation, easy handling, simple work-up and versatility.
Evaluation of dihydropyrimidin-(2H)-one analogues and rhodanine derivatives as tyrosinase inhibitors
Liu, Jinbing,Wu, Fengyan,Chen, Lingjuan,Hu, Jianming,Zhao, Liangzhong,Chen, Changhong,Peng, Liwang
supporting information; experimental part, p. 2376 - 2379 (2011/05/15)
A series of dihydropyrimidin-(2H)-one analogues and rhodanine derivatives were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. The results showed that some of the synthesized compounds exhibited
