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NCS-382 is a white powder substance that acts as an antagonist of γ-hydroxybutyric acid (GHB). It possesses antagonistic properties at GHB receptor sites, where it inhibits the cGMP increase and inositol phosphate accumulation induced by GHB in the hippocampus. Additionally, NCS-382 suppresses the GHB-induced modification of dopamine release in the striatum.

131733-92-1

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131733-92-1 Usage

Uses

Used in Pharmaceutical Industry:
NCS-382 is used as a pharmaceutical agent for its antagonistic properties against γ-hydroxybutyric acid (GHB). It is particularly useful in the development of treatments for conditions related to GHB receptor activity, such as neurological disorders and substance abuse.
Used in Research Applications:
In the field of research, NCS-382 is used as a research tool to study the effects of GHB on the central nervous system. It helps researchers understand the mechanisms of action of GHB and its role in various physiological processes, including the modulation of dopamine release in the striatum.
Used in Drug Development:
NCS-382 is used as a starting point for the development of new drugs targeting GHB receptors. Its antagonistic properties make it a valuable compound for designing and synthesizing novel therapeutic agents that can potentially treat a range of conditions associated with GHB receptor dysregulation.
Used in Neurological Applications:
NCS-382 is used as a therapeutic agent for neurological conditions that involve the dysregulation of GHB receptors. By antagonizing the effects of GHB, it may help alleviate symptoms and improve the quality of life for patients suffering from such conditions.

Biological Activity

γ -Hydroxybutyric acid antagonist, anticonvulsant.

Check Digit Verification of cas no

The CAS Registry Mumber 131733-92-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,7,3 and 3 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 131733-92:
(8*1)+(7*3)+(6*1)+(5*7)+(4*3)+(3*3)+(2*9)+(1*2)=111
111 % 10 = 1
So 131733-92-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H14O3.Na/c14-12(15)8-10-6-3-5-9-4-1-2-7-11(9)13(10)16;/h1-2,4,7-8,13,16H,3,5-6H2,(H,14,15);/q;+1/p-1/b10-8+;

131733-92-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name NCS-382,6,7,8,9-Tetrahydro-5-hydroxy-5H-benzocyclohept-6-ylideneaceticacid

1.2 Other means of identification

Product number -
Other names NCS-382 HYDRATE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:131733-92-1 SDS

131733-92-1Upstream product

131733-92-1Downstream Products

131733-92-1Related news

Stereoselectivity of NCS-382 (cas 131733-92-1) binding to γ-hydroxybutyrate receptor in the rat brain07/24/2019

γ-Hydroxybutyric acid (GHB), a naturally occurring metabolite of γ-aminobutyric acid (GABA), has been postulated to act both as a specific agonist of GHB receptors and as a weak GABAB receptor agonist. The racemic compound 6,7,8,9-tetrahydro-5-hydroxy-5H-benzocyclohept-6-ylideneacetic acid (RS...detailed

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