131738-96-0Relevant articles and documents
Linear Oligopeptides. Part 227. X-Ray Crystal and Molecular Structures of Two α-Helix-forming (Aib-L-Ala) Sequential Oligopeptides, p-BrBz-(Aib-L-Ala)5-OMe and pBrBz-(Aib-L-Ala)6-OMe
Benedetti, Ettore,Blasio, Benedetto Di,Pavone, Vincenzo,Pedone, Carlo,Santini Antonello,et al.
, p. 1829 - 1837 (1990)
A crystal-state structural analysis of pBrBz-(Aib-L-Ala)5-OMe tetrahydrate and pBrBz-(Aib-L-Ala)6-OMe dihydrate has been performed by X-ray diffarction.The decapeptide and dodecapeptide molecules are both basically α-helical with five and seven 1 - 5 intramolecular H-bonds, respectively.A similarity between the two structures is also seen near the C-terminus, where regularity of the α-helix is disrupted in favour of formation of intramolecular H-bonds of the 1 - 4 and 1 - 6 types.A brief comparison with parameters and interactions characteristic of the helices present in globular proteins has been made.