131747-46-1

Basic information

• Product Name: 4-TRIFLUOROMETHYL-PYRIDINE-2-METHANOL
• Synonyms: 4-TRIFLUOROMETHYL-PYRIDINE-2-METHANOL;(4-TRIFLUOROMETHYL-PYRIDIN-2-YL)-METHANOL;[4-(Trifluoromethyl)-2-pyridinyl]methanol;2-(Hydroxymethyl)-4-(trifluoromethyl)pyridine;2-PyridineMethanol, 4-(trifluoroMethyl)-;[4-(Trifluoromethyl)pyridin-2-yl]methanol, 2-(Hydroxymethyl)-alpha,alpha,alpha-trifluoro-4-picoline;4-(trifluoromethyl)-2-Pyridinemethanol
• CAS NO: 131747-46-1
• Molecular Formula: C₇H₆F₃NO
• Molecular Weight: 177.12
• Mol File: 131747-46-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 217.1 °C at 760 mmHg
• Flash Point: 85.1 °C
• Appearance: /
• Density: 1.362 g/cm³
• Vapor Pressure: 0.0788mmHg at 25°C
• Refractive Index: 1.462
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 13.16±0.10(Predicted)
• CAS DataBase Reference: 4-TRIFLUOROMETHYL-PYRIDINE-2-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-TRIFLUOROMETHYL-PYRIDINE-2-METHANOL(131747-46-1)
• EPA Substance Registry System: 4-TRIFLUOROMETHYL-PYRIDINE-2-METHANOL(131747-46-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 131747-46-1(Hazardous Substances Data)

Usage

General Description

4-Trifluoromethyl-pyridine-2-methanol is a chemical compound that features a pyridine ring with a trifluoromethyl group and a hydroxymethyl group attached to it. 4-TRIFLUOROMETHYL-PYRIDINE-2-METHANOL is commonly used as an intermediate in organic synthesis, particularly in the pharmaceutical and agrochemical industries. It can be used in the production of various compounds with biological activity, such as antifungal and antibacterial agents. Additionally, 4-Trifluoromethyl-pyridine-2-methanol can also be used as a building block in the synthesis of various drug molecules and other complex organic compounds.

InChI:InChI=1/C7H6F3NO/c8-7(9,10)5-1-2-11-6(3-5)4-12/h1-3,12H,4H2

Upstream product

• 67-56-1 methanol 
• 132470-83-8 4-(trifluoromethyl)pyridine-2-carbaldehyde 
• 175205-81-9 2-bromo-4-(trifluoromethyl)pyridine 
• 588702-62-9 4-(trifluoromethyl)-2-pyridinecarboxylic acid 
• 131748-17-9 4-Trifluoromethyl-2-picoline-N-oxide 
• 81565-18-6 2-chloro-4-trifluoromethyl pyridine 
• 131747-39-2 [4-(trifluoromethyl)pyridin-2-yl]methyl acetate 

Downstream Products

• 108337-81-1 2,6-dimethyl-4-(4-trifluoromethyl-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester 
• 215867-87-1 2-(chloromethyl)-4-(trifluoromethyl)pyridine 
• 132470-83-8 4-(trifluoromethyl)pyridine-2-carbaldehyde 

Relevant articles and documents

Photochemical C-H Silylation and Hydroxymethylation of Pyridines and Related Structures: Synthetic Scope and Mechanisms

Considering the synthetic relevance of heteroarenes in various areas ranging from organic synthesis to medicinal chemistry, developing practically simple methodologies to access functionalized heteroarenes is of a significant value. Described herein is an efficient approach for C-H silylation and hydroxymethylation of pyridines and related heterocycles by the combination of silanes or methanol with readily available N-methoxypyridinium ions with a low catalyst loading (2 mol %) under blue light irradiation. The synthetic importance of the developed reactions is demonstrated by the synthesis of biologically relevant compounds. Electron paramagnetic resonance spectroscopy, quantum yield measurements, and density-functional theory calculations allowed us to understand reaction mechanisms of both photocatalytic reactions.

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.

Synthesis method of 2-pyridylaldehyde derivative

The invention relates to the field of medical intermediates, in particular to a synthesis method of 2-pyridylaldehyde derivative. A synthesis path shown in the formula 1 is adopted, wherein X can be Cl or Br or CF3. Cheap starting raw materials are adopted, the use of hazardous materials which have large toxicity and are easily explosive is avoided, the cost of the product is greatly lowered, popularization and industrialized production are facilitated, and the synthesis method has the advantages of being low in cost, easy to operate, high in yield, easy to industrialize and the like. The formula 1 is shown in the description.