131747-63-2Relevant articles and documents
INHIBITORS OF RAF KINASES
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Paragraph 00297; 00300-00301, (2022/04/03)
Provided herein are inhibitors of receptor tyrosine kinase effector, RAF, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.
ANALOGS OF 2-PRALIDOXIME AS ANTIDOTES AGAINST ORGANOPHOSPHORUS NERVE AGENTS
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Paragraph 0079, (2020/02/23)
Provided herein are compounds useful in treating exposure to an organophosphorus compound, such as a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, such as sarin. Compositions, e.g. pharmaceutical compositions or dosage forms, comprising the compounds also are provided herein. Methods of treating a patient exposed to a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, e.g., an organophosphorus compound, such as sarin, also are provided.
2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties
Charoensutthivarakul, Sitthivut,Hong, W. David,Leung, Suet C.,Gibbons, Peter D.,Bedingfield, Paul T.P.,Nixon, Gemma L.,Lawrenson, Alexandre S.,Berry, Neil G.,Ward, Stephen A.,Biagini, Giancarlo A.,O'Neill, Paul M.
supporting information, p. 1252 - 1259 (2015/07/15)
A series of 2-pyridylquinolones has been prepared in 5-7 steps and through lead optimisation, antimalarial activity as low as 12 nM against Plasmodium falciparum (Pf) has been achieved. Compared with previous analogues in this series, selected molecules h
