13175-75-2

Basic information

• Product Name: 2'-diphenylphosphino-2-methoxymethylbiphenyl
• Synonyms: 2'-diphenylphosphino-2-methoxymethylbiphenyl
• CAS NO: 13175-75-2
• Molecular Weight: 382.442
• Mol File: 13175-75-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2'-diphenylphosphino-2-methoxymethylbiphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-diphenylphosphino-2-methoxymethylbiphenyl(13175-75-2)
• EPA Substance Registry System: 2'-diphenylphosphino-2-methoxymethylbiphenyl(13175-75-2)

Safety Data

• Hazardous Substances Data: 13175-75-2(Hazardous Substances Data)

Upstream product

• 13175-74-1 2'-bromo-2-methoxymethylbiphenyl 
• 1079-66-9 chloro-diphenylphosphine 
• 69200-16-4 2'-bromo-[1,1'-biphenyl]-2-carboxylic acid 
• 13175-73-0 (2'-bromo-biphenyl-2-yl)-methanol 
• 13379-29-8 2-bromo-2'-(bromomethyl)-1,1'-biphenyl 

Downstream Products

• 13175-92-3 9,10-dihydro-9,9-diphenyl-9-phosphoniaphenanthrene bromide 
• 13175-93-4 5,5-diphenyl-5λ⁵-phosphanthridine 
• 13175-77-4 (2'-methyl-[1,1'-biphenyl]-2-yl)diphenylphosphine oxide 

Relevant articles and documents

Mitigation of NADPH oxidase 2 activity as a strategy to inhibit peroxynitrite formation

Using high throughput screening-compatible assays for superoxide and hydrogen peroxide, we identified potential inhibitors of the NADPH oxidase (Nox2) isoform from a small library of bioactive compounds. By using multiple probes (hydroethidine, hydropropidine, Amplex Red, and coumarin boronate) with well defined redox chemistry that form highly diagnostic marker products upon reaction with superoxide (O2. ), hydrogen peroxide (H2O2), and peroxynitrite (ONOO), the number of false positives was greatly decreased. Selected hits for Nox2 were further screened for their ability to inhibit ONOO formation in activated macrophages. A new diagnostic marker product for ONOO is reported. We conclude that the newly developed high throughput screening/reactive oxygen species assays could also be used to identify potential inhibitors of ONOO formed from Nox2-derived O2 and nitric oxide synthase- derived nitric oxide.