131760-45-7 Usage
General Description
The chemical "(2alpha,5beta,7beta,10beta,13alpha)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-{[(2R)-2-hydroxy-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate" is a complex compound that belongs to the taxane class of anti-cancer drugs. It has a molecular structure that includes multiple acetyl, hydroxyl, and epoxy functional groups, as well as a benzoate moiety. (2alpha,5beta,7beta,10beta,13alpha)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-{[(2R)-2-hydroxy-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate is derived from the Pacific yew tree and has potent antitumor activity, functioning as a microtubule-stabilizing agent. It is commonly used in the treatment of various types of cancer, including breast, lung, and ovarian cancer, and is often administered in combination with other chemotherapy drugs. The acetyloxy and hydroxy groups on the compound's structure likely contribute to its biological activity and pharmacokinetic properties, and the benzoate ester may play a role in enhancing its solubility and stability.
Check Digit Verification of cas no
The CAS Registry Mumber 131760-45-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,7,6 and 0 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 131760-45:
(8*1)+(7*3)+(6*1)+(5*7)+(4*6)+(3*0)+(2*4)+(1*5)=107
107 % 10 = 7
So 131760-45-7 is a valid CAS Registry Number.
131760-45-7Relevant articles and documents
Biologically Active Taxol Analogues with Deleted A-Ring Side Chain Substituents and Variable C-2' Configurations
Swindell, Charles S.,Krauss, Nancy E.,Horwitz, Susan B.,Ringel, Israel
, p. 1176 - 1184 (2007/10/02)
Taxol (1), a potent inhibitor of cell replication, enhances the assembly of tubulin into stable microtubules and promotes the formation of microtubule bundles in cells.In addition to its unique mechanism of action, taxol exhibits unusual promise as an ant
