131769-78-3Relevant articles and documents
A Very Short Route to Fully Aromatic 2,3,8,9- and 2,3,8,9,12-Oxygenated Benzophenanthridines
Olugbade, Tiwalade A.,Waigh, Roger D.,Mackay, Simon P.
, p. 2657 - 2660 (2007/10/02)
Cyclisation of suitably substituted 2-benzylamino-2-phenylacetonitriles proceeds by rearrangement in sulphuric acid or anhydrous hydrogen fluoride, to give 3-aryl-1,2-dihydroisoquinolinones possessing all but two carbons of the benzophenanthridine ring system.These two carbon atoms are introduced in high yield by means of a modified Reformatski reaction and the resulting ester is cyclised in sulphuric acid, with concomitant dehydration and oxidation, to give the fully aromatic four-ring system in only four steps.