131771-41-0Relevant academic research and scientific papers
N-Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII
Ivanova, Jekaterīna,Carta, Fabrizio,Vullo, Daniela,Leitans, Janis,Kazaks, Andris,Tars, Kaspars,?alubovskis, Raivis,Supuran, Claudiu T.
, p. 3583 - 3589 (2017)
A series of N-substituted saccharins incorporating aryl, alkyl and alkynyl moieties, as well as some ring opened derivatives were prepared and investigated as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). The widespread cytosolic is
Synthesis and activity of selective MMP inhibitors with an aryl backbone
E. Barta, Thomas,P. Becker, Daniel,J. Bedell, Louis,A. De Crescenzo, Gary,J. McDonald, Joseph,E. Munie, Grace,Rao, Shashi,Shieh, Huey-Sheng,Stegeman, Roderick,M. Stevens, Anna,I. Villamil, Clara
, p. 2815 - 2817 (2007/10/03)
A series of novel, MMP-1 sparing arylhydroxamate sulfonamides with activity against MMP-2 and -13 is described. (C) 2000 Elsevier Science Ltd.
