131779-46-9

Basic information

• Product Name: 1,1-DIMETHYLETHYL 4-(1,2-BENZISOTHIAZOLE-3-YL)-1-PIPERAZINECARBOXYLATE
• Synonyms: 1,1-DIMETHYLETHYL 4-(1,2-BENZISOTHIAZOLE-3-YL)-1-PIPERAZINECARBOXYLATE;4-(1,2-Benzisothiazol-3-yl)-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester
• CAS NO: 131779-46-9
• Molecular Formula: C16H21N3O2S
• Molecular Weight: 319.42184
• Mol File: 131779-46-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Solubility: DCM
• CAS DataBase Reference: 1,1-DIMETHYLETHYL 4-(1,2-BENZISOTHIAZOLE-3-YL)-1-PIPERAZINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-DIMETHYLETHYL 4-(1,2-BENZISOTHIAZOLE-3-YL)-1-PIPERAZINECARBOXYLATE(131779-46-9)
• EPA Substance Registry System: 1,1-DIMETHYLETHYL 4-(1,2-BENZISOTHIAZOLE-3-YL)-1-PIPERAZINECARBOXYLATE(131779-46-9)

Safety Data

• Hazardous Substances Data: 131779-46-9(Hazardous Substances Data)

Usage

Uses

4-(1,2-Benzisothiazol-3-yl)-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of Ziprasidone (Z485010) related compounds.

Upstream product

• 291748-19-1 4-(4-chloro-[1,2,5]thiadiazol-3-yl)piperazine-1-carboxylic acid tert-butyl ester 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 87691-87-0 3-(1-piperazinyl)-1,2-benzisothiazole 

Relevant articles and documents

An Aryne-Based Route to Substituted Benzoisothiazoles

The combination of arynes, generated using fluoride from the corresponding 2-(trimethylsilyl)aryl triflates, and 3-hydroxy-4-aminothiadiazoles leads to the selective formation of 3-amino-substituted benzo[d]isothiazoles. Variation of the substitution pattern of the aryne precursor, and of the thiadiazole, is possible, with the target heterocycles being obtained in good to excellent yields. In all cases, use of 3-hydroxy-4-aminothiadiazoles leads to incorporation of the amino-substituent in the product heterocycle.

Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione

Various metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione which are particularly useful in the treatment of psychotic disorders, especially derivatives thereof which have been ox