131786-47-5

Usage

Uses

Used in Chemical Research:
5-Methyl-2-(2-pyridinyl)-1,3-thiazol-4-ol is used as a research compound for exploring its chemical properties and potential reactions within the field of organic chemistry. Its unique structure allows for investigation into the reactivity of the thiazol and pyridine rings, as well as the influence of the hydroxyl and methyl groups on its behavior.
Used in Pharmaceutical Investigations:
In the pharmaceutical industry, 5-Methyl-2-(2-pyridinyl)-1,3-thiazol-4-ol is used as a lead compound for drug discovery. Its specific structural features may offer opportunities for the development of new therapeutic agents, particularly in the areas of medicinal chemistry and drug design. Further research is required to understand its potential interactions with biological targets and its efficacy in treating specific conditions.

InChI:InChI=1/C9H8N2OS/c1-6-8(12)11-9(13-6)7-4-2-3-5-10-7/h2-5,12H,1H3

Upstream product

• 100-70-9 2-Cyanopyridine 
• 79-42-5 2-mercaptopropanoic acid 
• 6959-64-4 (+)-thiolactic acid 

Downstream Products

• 1279103-45-5 2-(2-Chloro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole 
• 1279103-46-6 5-(5-Methyl-2-pyridin-2-yl-thiazol-4-yl)-2-o-tolyl-1H-indole 
• 1279106-35-2 Benzenesulfonyl-2-(2-chloro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole 
• 1279106-39-6 Benzenesulfonyl-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-2-o-tolyl-1H-indole 

Relevant academic research and scientific papers

Assembly of T-Shaped Amphiphilic Thiazoles on the Air-Water Interface: Impact of Polar Chromophore Moieties, as Well as Dipolarity and π-Extension of the Chromophore on the Supramolecular Structure

The supramolecular structure essentially determines the properties of organic thin films. In this work, we systematically investigate the influence of the chromophore on the supramolecular structure formation at air-water interfaces by means of the Langmu

BENZOXAZINE DERIVATIVES AS CRAC MODULATORS

Compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with calcium release-activated calcium channels (CRAC).

AZABENZOXAZINE DERIVATIVES AS CRAC MODULATORS

Compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with calcium release-activated calcium channels (CRAC).

Catalytic enantioselective synthesis of tertiary thiols from 5h-thiazol-4-ones and nitroolefins: Bifunctional ureidopeptide-based bronsted base catalysis

Fully loaded: The ureidopeptide-based bifunctional Bronsted base 1 efficiently promotes the first direct catalytic Michael reaction of α-mercapto carboxylate surrogates with nitroolefins involving a fully substituted α-carbon atom construction. Copyright

Hydroxythiazole-based fluorescent probes for fluoride ion detection

This work describes the synthesis of five O-silyloxy-1,3-thiazoles and their use as fast-response "turn-on" probes for fluoride ion detection in polar aprotic solvents and in aqueous cetyltrimethylammonium bromide micellar medium. The fluoride-triggered d

INDOLE DERIVATIVES AS CRAC MODULATORS

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with calcium release-activated calcium channels (CRAC).

4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS

A composition for the inhibition of lipoxygenase enzymes comprising a pharmaceutically acceptable carrier and a compound of the formula: I wherein R1 and R2 are independently selected from the group consisting of alkyl, alkenyl, cycloalkyl, cycloalkenyl,

4-Hydroxythiazole Inhibitors of 5-Lipoxygenase

4-Hydroxythiazoles have been identified as potent inhibitors of 5-lipoxygenase in vitro exhibiting IC50's of less than 1 μM.An investigation of structure-activity relationships showed that the most potent inhibitors of this series are the 5-phenyl derivatives.The corresponding thiazolidin-4-one analogues were found to be relatively inactive.The 4-hydroxythiazoles were active inhibitors against 5-lipoxygenase in both intact rat polymorphonuclear leukocytes and human whole blood.The compounds were also selective inhibitors of 5-lipoxygenase, displaying only weak activity against other related enzymes, cyclooxygenase and 12- and 15-lipoxygenase.