131786-56-6

Basic information

• Product Name: 2-(4-nitrophenyl)-4-hydroxy-5-methylthiazole
• Synonyms: 2-(4-nitrophenyl)-4-hydroxy-5-methylthiazole
• CAS NO: 131786-56-6
• Molecular Weight: 236.251
• Mol File: 131786-56-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-nitrophenyl)-4-hydroxy-5-methylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-nitrophenyl)-4-hydroxy-5-methylthiazole(131786-56-6)
• EPA Substance Registry System: 2-(4-nitrophenyl)-4-hydroxy-5-methylthiazole(131786-56-6)

Safety Data

• Hazardous Substances Data: 131786-56-6(Hazardous Substances Data)

Usage

General Description

2-(4-nitrophenyl)-4-hydroxy-5-methylthiazole is a chemical compound with the molecular formula C11H9N3O3S. It contains a thiazole ring with a nitrophenyl group and a hydroxy and methyl group attached to it. 2-(4-nitrophenyl)-4-hydroxy-5-methylthiazole is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its potential biological activities. It is also known for its antibacterial and anti-inflammatory properties. Additionally, it has been studied for its potential use in the treatment of cancer and other diseases. This chemical is important for various research and industrial applications due to its unique structure and potential biological activities.

Upstream product

• 79-42-5 2-mercaptopropanoic acid 
• 619-72-7 4-nitrobenzonitrile 

Downstream Products

• 1395030-52-0 2-(4-aminophenyl)-5-methylthiazolidin-4-one 

Relevant articles and documents

Assembly of T-Shaped Amphiphilic Thiazoles on the Air-Water Interface: Impact of Polar Chromophore Moieties, as Well as Dipolarity and π-Extension of the Chromophore on the Supramolecular Structure

The supramolecular structure essentially determines the properties of organic thin films. In this work, we systematically investigate the influence of the chromophore on the supramolecular structure formation at air-water interfaces by means of the Langmu

4-Hydroxythiazole Inhibitors of 5-Lipoxygenase

4-Hydroxythiazoles have been identified as potent inhibitors of 5-lipoxygenase in vitro exhibiting IC50's of less than 1 μM.An investigation of structure-activity relationships showed that the most potent inhibitors of this series are the 5-phenyl derivatives.The corresponding thiazolidin-4-one analogues were found to be relatively inactive.The 4-hydroxythiazoles were active inhibitors against 5-lipoxygenase in both intact rat polymorphonuclear leukocytes and human whole blood.The compounds were also selective inhibitors of 5-lipoxygenase, displaying only weak activity against other related enzymes, cyclooxygenase and 12- and 15-lipoxygenase.