131796-81-1Relevant articles and documents
Dihydropyridine neuropeptide Y Y1 receptor antagonists
Poindexter, Graham S.,Bruce, Marc A.,LeBoulluec, Karen L.,Monkovic, Ivo,Martin, Scott W.,Parker, Eric M.,Iben, Larry G.,McGovern, Rachel T.,Ortiz, Astrid A.,Stanley, Jennifer A.,Mattson, Gail K.,Kozlowski, Michael,Arcuri, Meredith,Antal-Zimanyi, Ildiko
, p. 379 - 382 (2002)
Dihydropyridine 5a was found to be an inhibitor of neuropeptide Y1 binding in a high throughput 125I-PYY screening assay. Structure-activity studies around certain portions of the dihydropyridine chemotype identified BMS-193885 (6e)
DIHYDROPYRIDINE NPY ANTAGONISTS: PIPERAZINE DERIVATIVES
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, (2008/06/13)
A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperazine and homopiperazine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). STR1 As antagonists of NPY-induced feeding behavior, these compounds are e
DIHYDROPYRIDINE NPY ANTAGONISTS: NITROGEN HETEROCYCLIC DERIVATIVES
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, (2008/06/13)
A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of nitrogen heterocyclic derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). STR1 As antagonists of NPY-induced feeding behavior, these compounds are expected
Process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines
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, (2008/06/13)
A process for the optical resolution of racemic 1,4-dihydropyridines, containing isothioureido groups. Salification of racemic isothioureas with optically active acids produces diasteroisomeric mixtures of isothiouronium salts, that, using conventional techniques, are separated in the individual components to give optically pure isothioureides of 1,4-dihydropyridines and salts thereof with conventional acids. Said optically pure 1,4-dihydropyridines can then be subjected to desulphuration and to different transformations to give to other enantiomerically pure and therapeutically useful 1,4-dihydropyridines.
