131801-70-2Relevant academic research and scientific papers
Preparation of cyclohexanol derivatives and novel thioamide intermediates
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, (2008/06/13)
The preparation of compounds having the formula I STR1 where R1 is --CN, --CO--N(CH3)2 or --CS--N(CH3)2 and R2 is hydrogen, methyl or a removable protecting group is carried out by condensing a compound having the formula STR2 where M is lithium, sodium, potassium or halomagnesium and R3 is methyl or a removable protecting group in a solvent comprising 80-100% of one or more hydrocarbons and 0-20% of one or more ethers. The solvent enables less inconvenient reaction temperatures to be used and higher yields to be obtained. Compounds (I) are new per se where R1 is --CS--N(CH3)2. Compounds (I) are chemical intermediates for preparing N,N-dimethyl-2-(1-hydroxycyclohexyl)-2-(4-hydroxyphenyl or 4-methoxyphenyl) ethylamine and pharmaceutically acceptable salts thereof. These end products are antidepressants.
