1318151-43-7

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 15097-38-8 (carbobenzyloxymethylene)triphenylphosphorane 
• 160858-75-3 1-tert-butoxycarbonylisatin 
• 91-56-5 indole-2,3-dione 

Downstream Products

• 1448778-04-8 (2R,3S,4S)-2-benzyl 1'-tert-butyl 4-(nitromethyl)-2'-oxospiro[chroman-3,3'-indoline]-1',2-dicarboxylate 
• 1448778-18-4 (2'R,3S,4'S)-2'-benzyl 1-tert-butyl 4'-(nitromethyl)-2-oxo-1'-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-1,2'-dicarboxylate 

Relevant academic research and scientific papers

Remote Control of Axial Chirality: Synthesis of Spirooxindole-Urazoles via Desymmetrization of ATAD

For the first time, a desymmetrization strategy empowered the assembly of a class of optically pure spirooxindole-urazoles possessing an N-Ar stereogenic axis via remote control of axial chirality in an asymmetric three-component reaction. This transformation was realized by a tandem bisthiourea-catalyzed asymmetric Diels-Alder reaction and substrate-controlled asymmetric ene reaction. The driving force derived from aromatization and the high reactivity of 4-aryl-1,2,4-triazole-3,5-dione enophiles mediated the occurrence of the successive ene reaction under mild conditions.

Catalytic Generation of Donor-Acceptor Cyclopropanes under N-Heterocyclic Carbene Activation and their Stereoselective Reaction with Alkylideneoxindoles

Formylcyclopropanes undergo activation in the presence of an N-heterocyclic carbene catalyst generating a donor-acceptor cyclopropane intermediate with the ability to undergo ring-opening followed by formal [4+2] cycloaddition with alkylideneoxindoles. This enables the direct enantio- and diastereoselective synthesis of tetrahydropyrano[2,3-b]indoles through the use of a chiral NHC catalyst. (Figure presented.).