1318238-41-3Relevant academic research and scientific papers
Palladium/copper-catalyzed Di-α-arylation of acetic acid esters
Song, Bingrui,Himmler, Thomas,Goossen, Lukas J.
, p. 1688 - 1694 (2011)
A bimetallic palladium/copper catalyst system was found to effectively promote the diarylation of alkyl acetates with aryl halides under unprecedentedly mild conditions. The phenanthroline-copper-phosphine catalyst stabilizes the enolate intermediate to the extent that the deprotonation of esters can be achieved even with the mild base potassium phosphate. The palladium tri-tert-butylphosphine co-catalyst mediates the coupling of the resulting copper enolate with a wide variety of aryl halides with selective formation of the corresponding diarylacetic acid esters. Copyright
