1318259-31-2Relevant academic research and scientific papers
Synthesis and hydrolysis kinetic study of few co-drugs of propranolol and other antihypertensive drugs
Baidya, Mayukh,Das, Amit Kumar
body text, p. 173 - 178 (2012/01/13)
The different acyl halide analogs of propranolol were synthesized by reacting Propanolol with different acyl anhydrides in toluene medium. The derivatives were reacted with thionyl chloride to get propranolol hemi acyl chloride. Finally the co-drugs were synthesized by reacting propranolol hemi acyl chloride with different classes of antihypertensive drugs like Nifedepine (PSN,PMN,PPN), Hydrochlorthiazide (PSH, PMH, PPH) and Acetazolamide(PSA, PMA, PPA) by ester linkage. The structure of the synthesized derivative of propranolol analogs were confirmed by M P, TLC, IR and NMR data.
