131833-48-2

Upstream product

• 68691-09-8 4,5,6,6a-Tetrahydro-3,5,5-trimethyl-2(1H)-pentalenone 
• 131833-49-3 Methyl 4,4-Dimethyl-2-oxo-1-(2-oxobutyl)-2-cyclopentanecarboxylate 
• 131833-50-6 Methyl 4,4-Dimethyl-1-(2-methylenebutyl)-2-oxocyclopentanecarboxylate 
• 131833-61-9 (3aα,6aα)-1,2,3,3a,6,6a-Hexahydro-2,2,4-trimethyl-3a-(phenylmethoxy)pentalene 
• 131833-54-0 (1aα,3aα,6aα)-Hexahydro-1,5,5-trimethyl-2-oxo-3H-pentalen<1,6a-b>oxirene 
• 131833-55-1 (3aα,6aα)-1,3,6,6a-Tetrahydro-2,2,4-trimethyl-3a(2H)-pentalenol 
• 60585-44-6 methyl 4,4-dimethyl-2-oxocyclopentanecarboxylate 
• 131833-56-2 (1R^*,2S^*)-2-Acetyl-4,4-dimethyl-2-(phenylmethoxy)cyclopentanecarboxaldehyde 

Relevant academic research and scientific papers

1,3-Elimination Reactions of (3,4-Epoxybutyl)stannanes. Approach to the Synthesis of Hirsutene

An advanced tricyclic precursor of hirsutene (3) was prepared by a 1,3-elimination reaction of spirocyclic epoxy stannane (7b).Compound 7b was synthesized efficiently from hydroxycyclohexenone 8b by conjugate addition of 2CuLi, Wittig methylenation, and VO(acac)2-catalyzed epoxidation.Intermediate 8b was prepared in five steps from the known enone 9 in 18percent overall yield.An improved synthesis makes compound 9 available in four efficient steps from keto ester 12.