131838-93-2

Basic information

• Product Name: N-(4-chloro-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide
• Synonyms: N-(4-chloro-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide
• CAS NO: 131838-93-2
• Molecular Weight: 319.831
• Mol File: 131838-93-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-chloro-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chloro-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide(131838-93-2)
• EPA Substance Registry System: N-(4-chloro-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide(131838-93-2)

Safety Data

• Hazardous Substances Data: 131838-93-2(Hazardous Substances Data)

Upstream product

• 131838-92-1 2-cyclohexyl-2-hydroxy-N-(4-hydroxy-2-butynyl)-2-phenylacetamide 
• 131838-91-0 2-chloro-2-cyclohexyl-N-(4-hydroxy-2-butynyl)-2-phenylacetamide 
• 92298-22-1 2-chloro-2-cyclohexyl-2-phenylacetyl chloride 

Downstream Products

• 131838-96-5 2-cyclohexyl-N-(4-dimethylamino-2-butynyl)-2-hydroxy-2-phenylacetamide 
• 201942-95-2 (-)-2-cyclohexyl-N-(4-dimethylamino-2-butynyl)-2-hydroxy-2-phenylacetamide 
• 131838-96-5 (+)-2-cyclohexyl-N-(4-dimethylamino-2-butynyl)-2-hydroxy-2-phenylacetamide 
• 144314-32-9 N-[4-(3 Azabicyclo[3.2.2]nonan-3-yl)-2-butynyl]-2-cyclohexyl-2-hydroxy-2-phenylacetamide 
• 131839-03-7 N-[4-(Ethoxycarbonylmethyl)amino-2-butynyl]-2-cyclohexyl-2-hydroxy-2-phenylacetamide 
• 131838-97-6 N-(4-Methylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide 
• 144314-23-8 N-[4-(2-Hydroxymethylpiperidino)-2-butynyl]-2-cyclohexyl-2-hydroxy-2-phenylacetamide 
• 131839-11-7 N-[4-(4-Methyl-1-piperazinyl)-2-butynyl]-2-cyclohexyl-2-hydroxy-2-phenylacetamide 
• 131839-10-6 N-(4-Morpholino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide 

Relevant articles and documents

Agents for the treatment of overactive detrusor. III. Synthesis and structure-activity relationships of N-(4-amino-2-butynyl)acetamide derivatives

A series of N-(4-amino-2-butynyl)acetamides were synthesized and examined for their inhibitory activity on detrusor contraction and mydriatic activity as an index of anticholinergic side effect. Among those compounds synthesized, (+)-2-cyclohexyl-N-(4-dimethylamino-2-butynyl)-2-hydroxy-2-phenylaceta mide hydrochloride ((+)-13b·HCl), 2-cyclohexyl-2-hydroxy-N-(4-methylamino-2-butynyl)-2-phenylacetamide hydrochloride (13c·HCl), N-(4-dimethylamino-2-butynyl)-2,2-diphenyl-2-hydroxyacetamide hydrochloride (14·HCl), and 2,2-diphenyl-N-(4-ethylamino-2-butynyl)-2-hydroxyacetamide hydrochloride (14b·HCl) showed equipotent inhibitory activity on detrusor contraction to oxybutynin (1) and less mydriatic activity. Further evaluation of these compounds as an agent for the treatment of overactive detrusor has been examined.