131839-59-3

Upstream product

• 93188-88-6 Chlor-cyclopentyl-phenyl-acetylchlorid 
• 123-91-1 1,4-dioxane 
• 53913-95-4 N,N-dimethylbutin-2-yl-1,4-diamine 
• 427-49-6 2-cyclopentyl-2-hydroxy-2-phenylacetic acid 

Relevant academic research and scientific papers

Agents for the treatment of overactive detrusor. III. Synthesis and structure-activity relationships of N-(4-amino-2-butynyl)acetamide derivatives

A series of N-(4-amino-2-butynyl)acetamides were synthesized and examined for their inhibitory activity on detrusor contraction and mydriatic activity as an index of anticholinergic side effect. Among those compounds synthesized, (+)-2-cyclohexyl-N-(4-dimethylamino-2-butynyl)-2-hydroxy-2-phenylaceta mide hydrochloride ((+)-13b·HCl), 2-cyclohexyl-2-hydroxy-N-(4-methylamino-2-butynyl)-2-phenylacetamide hydrochloride (13c·HCl), N-(4-dimethylamino-2-butynyl)-2,2-diphenyl-2-hydroxyacetamide hydrochloride (14·HCl), and 2,2-diphenyl-N-(4-ethylamino-2-butynyl)-2-hydroxyacetamide hydrochloride (14b·HCl) showed equipotent inhibitory activity on detrusor contraction to oxybutynin (1) and less mydriatic activity. Further evaluation of these compounds as an agent for the treatment of overactive detrusor has been examined.

Novel substituted-acetamide compound and a process for the preparation thereof

Compounds of the formula STR1 wherein R1 is aryl which may have one or more suitable substituent(s), R2 is aryl which may have one or more suitable substituent(s), lower alkyl or cyclo(lower)alkyl, R3 is hydrogen, hydroxy,