131844-00-3Relevant academic research and scientific papers
Potential histamine H2-receptor antagonists. Synthesis, conformational studies and activity of novel 3-oxo-1,2,5-thiadiazole 1,1-dioxide derivatives.
Aran,Davila,Frances,Goya,Gras,Martinez,Mylonakis,Pardo
, p. 1003 - 1007 (2007/10/02)
New histamine H2-receptor antagonists bearing a novel "urea equivalent", the 3-oxo-1,2,5-thiadiazole 1,1-dioxide ring, have been synthesized in a transamination reaction. Open chain derivatives have also been obtained. Theoretical conformational analysis of the compounds has been carried out using a molecular modelling program. Semiempirical CNDO/2 calculations have also been performed. The antisecretory and cytoprotective activities of the compounds have been evaluated.
Reactivity of 4-Amino-2-benzyl-2,3-dihydro-3-oxo-1,2,5-thiadiazole 1,1-Dioxide towards Amines: Synthesis of potential Histamine H2-Receptor Antagonists
Aran, Vicente J.,Ruiz, Jose R.,Stud, Manfred
, p. 955 - 960 (2007/10/02)
The reaction of the title compound (1) with sodium or ammonium hydroxides yielded the corresponding ring-opened derivatives (2) and (3).Reaction of compound (1) with amines afforded, depending on the basicity of the latter and the reaction conditions, pro
