1318780-40-3Relevant academic research and scientific papers
Synthesis and biological activity of novel L-amino acid based analgesic compounds
Pan, Junzhu,Wang, Qianqian,He, Gu,Ouyang, Liang,Guo, Li
, p. 359 - 364 (2011/10/31)
Synthesis and analgesic activity studies of a series of L-amino acid based compounds were described. These compounds were designed as potential N-type Calcium Channel Blockers and their structures were confirmed by 1H NMR and ESI-MS spectra. Some of the compounds exhibited significant analgesic activity in Mouse Hot-Plate tests. According to the data of pharmacological experiments, we carried out preliminary structure-activity studies and the results indicated that this kind of compounds was useful for the development of new analgesic drugs.
