1318780-82-3Relevant articles and documents
Unique phenyl ether type biflavonoids, zizyflavosides A and B with biomimetic synthesis for zizyflavoside A
Mostafa, Mahmoud,Takano, Fumihide,Ohta, Tomihisa
, p. 2497 - 2509 (2011/04/24)
During our investigation of Zizyphus spina-christi (L.) Willd. leaves for anti-inflammatory activity, eight compounds were characterized. Two are new phenyl ether type biflavonoids, which were assigned as zizyflavosides A (1) and B (2). The structures of 1 and 2 were determined by spectroscopic analyses including 1D, 2D NMR and MS spectroscopic and chemical data. The other isolated compounds were known flavonoids kaempferol-3-O-rutinoside (5), quercetin-3-O-rutinoside (6), 3',5'-di-C-β-D-glucosylphloretine (7), quercetin-3-O-[β-D-xylosyl-(1→2)-α-L-rhamnoside] -4'-O-α-L-rhamnoside (8), epiafzelechin (9) and quercetin-3-O-[β-D- xylosyl-(1→2)-α-L-rhamnoside] (10). Zizyflavoside A was synthesized from quercetin-3-O-rutinoside and kaempferol-3-O-rutinoside using laccase as an enzyme and this biomimetic synthesis could be indication to its biosynthetic pathway. The Japan Institute of Heterocyclic Chemistry.