1318781-89-3Relevant academic research and scientific papers
Novel β-amino acid derivatives as inhibitors of cathepsin A
Ruf, Sven,Buning, Christian,Schreuder, Herman,Horstick, Georg,Linz, Wolfgang,Olpp, Thomas,Pernerstorfer, Josef,Hiss, Katrin,Kroll, Katja,Kannt, Aimo,Kohlmann, Markus,Linz, Dominik,Hübschle, Thomas,Rütten, Hartmut,Wirth, Klaus,Schmidt, Thorsten,Sadowski, Thorsten
, p. 7636 - 7649 (2012/11/07)
Cathepsin A (CatA) is a serine carboxypeptidase distributed between lysosomes, cell membrane, and extracellular space. Several peptide hormones including bradykinin and angiotensin I have been described as substrates. Therefore, the inhibition of CatA has
OXYGEN-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
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Page/Page column 130; 139, (2011/08/21)
The present invention relates to compounds of the formula I, wherein A, D, E, G, R10, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compound
