1318796-68-7

Upstream product

• 5396-89-4 benzyl acetoacetate 
• 66584-17-6 C₁₁H₁₃NO₃ 

Downstream Products

• 1454283-90-9 5-benzyl 2-ethyl 6-methylpyridine-2,5-dicarboxylate 
• 1454283-73-8 5-benzyl 2-ethyl 1,4-dihydro-6-methyl-4-phenylpyridine-2,5-dicarboxylate 
• 1454283-74-9 5-benzyl 2-ethyl 6-methyl-4-phenylpyridine-2,5-dicarboxylate 
• 1454283-85-2 5-benzyl 2-methyl 4-(4-methoxyphenyl)-6-methylpyridine-2,5-dicarboxylate 
• 1454283-86-3 5-benzyl 2-methyl 4-(4-(methoxycarbonyl)phenyl)-6-methylpyridine-2,5-dicarboxylate 
• 1454283-87-4 5-benzyl 2-methyl 4-(2-chlorophenyl)-6-methylpyridine-2,5-dicarboxylate 
• 1454283-88-5 dibenzyl 4,6-dimethylpyridine-2,5-dicarboxylate 
• 1454283-89-6 5-benzyl 2-ethyl 4-benzyl-6-methylpyridine-2,5-dicarboxylate 
• 1454283-92-1 C₁₈H₁₉NO₆ 
• 1454283-91-0 dimethyl 4-(4-(benzyloxy)-4-oxobut-2-en-2-ylimino)pent-2-enedioate 
• 1454283-93-2 5-benzyl 2,4-dimethyl 6-methylpyridine-2,4,5-tricarboxylate 
• 1454283-94-3 5-benzyl 2,4-diethyl 3,6-dimethylpyridine-2,4,5-tricarboxylate 
• 1454283-95-4 5-benzyl 2-methyl 4-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)-6-methylpyridine-2,5-dicarboxylate 
• 1454283-97-6 benzyl 6-(diethoxyphosphoryl)-2-methyl-4-phenylnicotinate 

Relevant academic research and scientific papers

Organocatalyzed nucleophilic addition of pyrazoles to 2: H -azirines: Asymmetric synthesis of 3,3-disubstituted aziridines and kinetic resolution of racemic 2 H -azirines

The first organocatalytic asymmetric nucleophilic addition of arylpyrazoles to 2H-azirines and kinetic resolution of racemic 2H-azirines have been realized. Chiral aziridines were obtained with up to 98% yields and up to 99.9% ee. Meanwhile, simply changing the ratio of reactants, optically active 2H-azirines were recovered in good yields with excellent enantioselectivities.

Synthesis of unsymmetrical pyrazines based on ?±-diazo oxime ethers

Synthesis of unsymmetrically substituted pyrazines has been a challenge. The reactivity of ?±-imino carbenoids derived from ?±-diazo oxime ethers has been exploited for pyrazine synthesis, in which the reaction of ?±-diazo oxime ethers with 2H-azirines provides highly substituted pyrazines in good to excellent yields.

RhII-catalyzed [3+2] cycloaddition of 2 H-azirines with N-sulfonyl-1,2,3-triazoles

RhII-catalyzed intermolecular [3+2] cycloaddition of 2 H-azirines with N-sulfonyl-1,2,3-triazoles is disclosed, in which a series of fully functionalized pyrroles is produced via rhodium azavinyl carbene intermediates. A distinct feature of this reaction is that the azavinyl carbene serves as a [2 C] equivalent, instead of as [1 C] or aza-[3 C] synthons, which have been reported previously in cyclopropanations and [3 + n] cycloadditions. Moreover, this methodology has also been successfully applied in the total synthesis of URB447 as well as the formal synthesis of Atorvastatin (Lipitor).

Synthesis of pyridines by carbenoid-mediated ring opening of 2H-azirines

Roaming the range: The title reaction tolerates a wide range of substituents on the resulting pyridine ring using mild reaction conditions (see scheme; esp=α,α,α′,α′-tetramethyl-1,3- benzenedipropionic acid). The formation of the key intermediate is catal