1318797-53-3

Upstream product

• 83-87-4 D-Mannose pentaacetate 
• 533-58-4 2-Iodophenol 
• 871311-12-5 2-ethynylphenyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 
• 871311-11-4 2-iodophenyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 

Downstream Products

• 871311-15-8 bis[2-(α-D-mannopyranosyloxy)phenyl]acetylene 

Relevant academic research and scientific papers

Synthesis of a small library of bivalent α-d-mannopyranosides for lectin cross-linking

A small library of bivalent α-d-mannopyranosides having rigid linkers was constructed in order to evaluate the effects of inter-saccharide distances upon multivalent binding interactions with plant and bacterial lectins. To this end, iodoaryl and propargyl α-d-mannopyranosides were synthesized and the former treated with TMS-acetylene under palladium chemistry to provide their corresponding ethynylaryl derivatives. A library of 15 dimeric members was then obtained using Lewis acid catalyzed glycosidation, aryl-aryl homocoupling, transition metal catalyzed Sonogashira cross-coupling reactions, and oxidative Glaser homocoupling.