1318929-46-2Relevant academic research and scientific papers
Metal-free hydroamination of alkynes: A mild and concise synthesis of thiazolo[3,2- a ]indoles and their cytotoxic activity
Bhave, Vishakha S.,Hojo, Ryoga,Jha, Mukund,Rhodes, Steven,Short, Spencer
, p. 4263 - 4270 (2019)
A metal-free, mild and efficient method for the synthesis of thiazolo[3,2- a ]indoles has been developed starting from indoline-2-thiones. The reaction methodology involves first the formation of thermally labile 2-(prop-2-ynylthio)-1 H -indole intermedia
One-pot regioselective synthesis of 3-benzylthiazolo[3,2-a]indoles by sequential sonogashira coupling followed by triethylamine-induced cyclization
Majumdar,Nath, Sanjay
experimental part, p. 1413 - 1418 (2011/06/27)
A number of 2-(prop-2-ynylthio)-1H-indoles have been utilized for the synthesis of 3-benzylthiazolo[3,2-a]indoles by Sonogashira acetylide-coupling followed by triethylamine-induced regioselective cyclization in a one-pot operation. The cyclization is dependent on the nature of the substituents on the phenyl ring of the substrates. Georg Thieme Verlag Stuttgart New York.
