13191-02-1

Basic information

• Product Name: 6-chloro-3-phenyl-2,4(1H,3H)-quinazolinedione
• Synonyms: 6-chloro-3-phenyl-2,4(1H,3H)-quinazolinedione
• CAS NO: 13191-02-1
• Molecular Weight: 272.691
• Mol File: 13191-02-1.mol

Chemical Properties

• CAS DataBase Reference: 6-chloro-3-phenyl-2,4(1H,3H)-quinazolinedione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-3-phenyl-2,4(1H,3H)-quinazolinedione(13191-02-1)
• EPA Substance Registry System: 6-chloro-3-phenyl-2,4(1H,3H)-quinazolinedione(13191-02-1)

Safety Data

• Hazardous Substances Data: 13191-02-1(Hazardous Substances Data)

Upstream product

• 701-73-5 methyl N-phenyldithiocarbamate 
• 86672-62-0 Potassium; 2-amino-5-chloro-benzoate 
• 84772-27-0 6-chloro-3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one 
• 4340-77-6 4-chloroazobenzene 
• 201230-82-2 carbon monoxide 
• 219487-62-4 5-chloro-2-nitro-N-phenylbenzamide 
• 62-53-3 aniline 
• 103-71-9 phenyl isocyanate 
• 31797-16-7 5-Chloro-2-(3-phenyl-ureido)-benzoic acid methyl ester 
• 84772-27-0 6-chloro-3-phenyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one 

Downstream Products

• 635-21-2 5-chloroanthranilic acid 

Relevant articles and documents

Remarkable conversion of 2-thioxo-2,3-dihydroquinazolin-4(1H)-ones into the corresponding quinazoline-2,4(1H,3H)-diones: Spectroscopic analysis and X-ray crystallography

A simple and efficient new synthetic method to obtain 3-substituted quinazolin-2,4-diones 9.16 by the reaction of 3-substituted 2- thioxo-quinazolin-4-ones 1.8 with sodamide under mild conditions was presented. The structure of the newly synthesized compounds was determined by infrared spectroscopy, UV-visible spectroscopy, nuclear magnetic resonance, and single-crystal X-ray crystallographic analysis. The crystal structure of 6-methyl-3-phenylquinazoline-2,4(1H,3H)-dione (11) [C15H12N2O2: MF. 252.27, triclinic, P-1, a = 7.8495 (13) ?, b= 12.456 (2) ?, c = 13.350 (2) ?, α = 103.322 (3)°, β = 90.002 (3)°, γ = 102.671 (4)°, V. 1237.5 (3) ?3, Z= 4, R = 0.0592, wR= 0.1699, S= 1.039] was determined. In the crystal cell, two identical conformers of compound 11 were found connected by intramolecular hydrogen bonds, responsible for the favourable occurrence of these two independent molecules.

Specific inhibitors of puromycin-sensitive aminopeptidase with a 3-(halogenated phenyl)-2,4(1H,3H)-quinazolinedione skeleton

Specific puromycin-sensitive aminopeptidase (PSA) inhibitors with a 3-(halogenated phenyl)-2,4(1H,3H)-quinazolinedione skeleton were prepared and their structure-activity relationships were investigated. The nature (F, Cl or Br), number and position(s) of the halogen atom(s) introduced into the 3-phenyl group were concluded to be critical determinants of the inhibitory activity.

Metal and phosgene-free synthesis of 1H-quinazoline-2,4-diones by selenium-catalyzed carbonylation of o-nitrobenzamides

1H-Quinazoline-2,4-diones were efficiently synthesized by selenium-catalyzed carbonylation of o-nitrobenzamides under relatively mild conditions. In situ-generated carbonyl selenide (SeCO) is proposed to initiate the catalytic carbonylation. Thus, a concise transition metal and phosgene-free synthetic route to potentially bioactive-substituted 1H-quinazoline-2,4-dione derivatives has been developed.