131911-07-4Relevant academic research and scientific papers
Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain
Cuzzucoli Crucitti, Giuliana,Métifiot, Mathieu,Pescatori, Luca,Messore, Antonella,Madia, Valentina Noemi,Pupo, Giovanni,Saccoliti, Francesco,Scipione, Luigi,Tortorella, Silvano,Esposito, Francesca,Corona, Angela,Cadeddu, Marta,Marchand, Christophe,Pommier, Yves,Tramontano, Enzo,Costi, Roberta,Di Santo, Roberto
, p. 1915 - 1928 (2015/04/27)
The development of HIV-1 dual inhibitors is a highly innovative approach aimed at reducing drug toxic side effects as well as therapeutic costs. HIV-1 integrase (IN) and reverse transcriptase-associated ribonuclease H (RNase H) are both selective targets
Differential Reactivity of β-Amino Enones and 3-Dimethylaminoacrylaldehyde towards α-Amino Derivatives
Alberola, Angel,Andres, Jose M.,Gonzalez, Alfonso,Pedrosa, Rafael,Vicente, Martina
, p. 2681 - 2685 (2007/10/02)
Unsubstituted β-amino enones react with α-amino derivatives by a well established route with implies a fast transamination process - 1,4-addition followed by elimination - and cyclodehydration of the intermediate to 3-functionalized pyrroles.In contrast, 3-dimethylaminoacrylaldehyde undergoes 1,2-addition followed by cyclization to give the final 2-substituted pyrroles.Isolation of the intermediates supports the proposed mechanism for each reaction.
