131916-17-1

Basic information

• Product Name: 2H-1,4-Oxazine-6-carboxylic acid, 3,5-dichloro-2-oxo-, methyl ester
• Synonyms: 2H-1,4-Oxazine-6-carboxylic acid, 3,5-dichloro-2-oxo-, methyl ester
• CAS NO: 131916-17-1
• Molecular Formula: C6H3Cl2NO4
• Molecular Weight: 224
• Mol File: 131916-17-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 133-134 °C
• Boiling Point: 270.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.71±0.1 g/cm3(Predicted)
• PKA: -6.16±0.40(Predicted)
• CAS DataBase Reference: 2H-1,4-Oxazine-6-carboxylic acid, 3,5-dichloro-2-oxo-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,4-Oxazine-6-carboxylic acid, 3,5-dichloro-2-oxo-, methyl ester(131916-17-1)
• EPA Substance Registry System: 2H-1,4-Oxazine-6-carboxylic acid, 3,5-dichloro-2-oxo-, methyl ester(131916-17-1)

Safety Data

• Hazardous Substances Data: 131916-17-1(Hazardous Substances Data)

Upstream product

• 79-37-8 oxalyl dichloride 
• 87223-69-6 methyl 2-cyano-2-trimethylsilyloxyacetate 

Relevant articles and documents

A General Synthesis of 3,5-Dihalo-2H-1,4-oxazin-2-ones from Cyanohydrins

In a novel approach starting from O-trimethylsilyl protected or unprotected cyanohydrins and oxalyl chloride or bromide, a series of unknown 6-substituted 3,5-dihalo-2H-1,4-oxazin-2-ones were prepared.The method was shown to be efficient for various types of cyanohydrins; however cyclization was not obtained with cyanohydrins containing bulky substituents, electron-rich aryl or heteroaryl groups.A mechanism is proposed.