131918-60-0 Usage
General Description
19-nor-Alfacalcidol is a synthetic analog of vitamin D used as a therapeutic agent for the treatment of secondary hyperparathyroidism, osteodystrophy, and renal osteopathy in patients with chronic kidney disease. It works by modulating calcium and phosphate metabolism, promoting the absorption of calcium from the intestines and preventing the release of parathyroid hormone. This helps to maintain proper levels of calcium and phosphate in the body, ultimately supporting bone health and regulating mineral levels. It is structurally similar to alfacalcidol but lacks the methyl group at the 19th position, which affects its bioactivity and metabolism, making it a potential option for patients who cannot tolerate other forms of vitamin D therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 131918-60-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,9,1 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 131918-60:
(8*1)+(7*3)+(6*1)+(5*9)+(4*1)+(3*8)+(2*6)+(1*0)=120
120 % 10 = 0
So 131918-60-0 is a valid CAS Registry Number.
131918-60-0Relevant articles and documents
A general approach to the synthesis of enantiopure 19-nor-Vitamin D 3 and its C-2 phosphate analogs prepared from cyclohexadienyl sulfone
Sikervar, Vikas,Fleet, James C.,Fuchs, Philip L.
, p. 9077 - 9079,3 (2020/08/31)
A synthesis of enantiopure 19-nor-Vitamin D3 and its C-2 substituted cyclic phosphate analogs is achieved via in situ trapping of an α-sulfonyl anion with a CD-ring allyl chloride and 1,2-eliminative desulfonylation exploiting the basic properties of TBAF. The A-ring is prepared via anti-selective dithiane addition to vinyl sulfone and LiBH4 mediated sequential bis reduction of an epoxy vinyl sulfone.
