131942-76-2Relevant academic research and scientific papers
SYNTHESIS OF SOME NEW 3-ARYLOXYMETHYL-4-PHENYL-5-(N-SUBSTITUTED CARBOXYAMIDOMETHYL THIO)-s-TRIAZOLES
Awad, Ibrahim M. A.,Abdel-Rahman, Abdu E.,Bakhite, Etify A.
, p. 63 - 71 (2007/10/02)
3-Aryloxymethyl-4-phenyl-5-mercapto-s-triazoles (1a-c) have been synthesized and reacted with N-chloroacetyl derivatives of aromatic and/or heterocyclic amines to yield 5-(N-aryl/heterocyclyl)-carboxamidomethyl thio-s-triazole derivatives 2a-u and 3a-i respectively.Reaction of 1a-c with ethyl chloroacetate gave the corresponding esters 4a-c which were reacted with hydrazine hydrate to give hydrazides 5a-c.Condensation of 5a-c with aromatic aldehydes gave Schiff's bases 6a-u which on cycloaddition reaction with thioglycolic acid yielded 4-thiazolidinones 7a-g.Some of these compounds were screened in vitro for their antibacterial activities.
