131942-78-4

Basic information

• Product Name: N-(4-acetylphenyl)-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
• Synonyms: N-(4-acetylphenyl)-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
• CAS NO: 131942-78-4
• Molecular Formula: C₂₅H₂₂N₄O₃S
• Molecular Weight: 458.53218
• Mol File: 131942-78-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-acetylphenyl)-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-acetylphenyl)-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide(131942-78-4)
• EPA Substance Registry System: N-(4-acetylphenyl)-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide(131942-78-4)

Safety Data

• Hazardous Substances Data: 131942-78-4(Hazardous Substances Data)

Upstream product

• 38283-38-4 4-(2-chloroacetamido)acetophenone 
• 21358-13-4 2-[3-phenoxymethyl-4-phenyl-1,2,4-triazole]-5-thiol 

Relevant articles and documents

SYNTHESIS OF SOME NEW 3-ARYLOXYMETHYL-4-PHENYL-5-(N-SUBSTITUTED CARBOXYAMIDOMETHYL THIO)-s-TRIAZOLES

3-Aryloxymethyl-4-phenyl-5-mercapto-s-triazoles (1a-c) have been synthesized and reacted with N-chloroacetyl derivatives of aromatic and/or heterocyclic amines to yield 5-(N-aryl/heterocyclyl)-carboxamidomethyl thio-s-triazole derivatives 2a-u and 3a-i respectively.Reaction of 1a-c with ethyl chloroacetate gave the corresponding esters 4a-c which were reacted with hydrazine hydrate to give hydrazides 5a-c.Condensation of 5a-c with aromatic aldehydes gave Schiff's bases 6a-u which on cycloaddition reaction with thioglycolic acid yielded 4-thiazolidinones 7a-g.Some of these compounds were screened in vitro for their antibacterial activities.